eF-site ID 1h2y-A PDB Code 1h2y Chain A click to enlarge Title PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL Classification HYDROLASE Compound PROLYL ENDOPEPTIDASE Source null (PPCE_PIG) Sequence A:  MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTK AFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHF KKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDG AKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGT ETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWV KLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTD PEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTS FLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQI FYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGFGGFNISI TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGIL ANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLV ATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADH DDRVVPLHSLKFIATLQYIVGRSRKQNNPLLIHVDTKAGH GAGKPTAKVIEEVSDMFAFIARCLNIDWIP Description Functional site 1) chain A residue 235 type sequence M description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 2) chain A residue 473 type sequence F description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 3) chain A residue 476 type sequence F description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 4) chain A residue 554 type sequence S description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 5) chain A residue 555 type sequence N description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 6) chain A residue 580 type sequence V description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 7) chain A residue 595 type sequence W description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 8) chain A residue 599 type sequence Y description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 9) chain A residue 643 type sequence R description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 10) chain A residue 680 type sequence H description BINDING SITE FOR RESIDUE ZPR A 791 source : AC1 11) chain A residue 118 type sequence I description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 12) chain A residue 119 type sequence L description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 13) chain A residue 120 type sequence S description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 14) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 15) chain A residue 446 type sequence D description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 16) chain A residue 522 type sequence N description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 17) chain A residue 525 type sequence N description BINDING SITE FOR RESIDUE GOL A 792 source : AC2 18) chain A residue 568 type sequence P description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 19) chain A residue 569 type sequence D description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 20) chain A residue 571 type sequence F description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 21) chain A residue 628 type sequence I description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 22) chain A residue 629 type sequence Q description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 23) chain A residue 631 type sequence P description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 24) chain A residue 668 type sequence N description BINDING SITE FOR RESIDUE GOL A 793 source : AC3 25) chain A residue 239 type sequence E description BINDING SITE FOR RESIDUE GOL A 794 source : AC4 26) chain A residue 291 type sequence D description BINDING SITE FOR RESIDUE GOL A 794 source : AC4 27) chain A residue 292 type sequence Y description BINDING SITE FOR RESIDUE GOL A 794 source : AC4 28) chain A residue 285 type sequence N description BINDING SITE FOR RESIDUE GOL A 795 source : AC5 29) chain A residue 306 type sequence R description BINDING SITE FOR RESIDUE GOL A 795 source : AC5 30) chain A residue 323 type sequence E description BINDING SITE FOR RESIDUE GOL A 795 source : AC5 31) chain A residue 226 type sequence A description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 32) chain A residue 227 type sequence E description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 33) chain A residue 228 type sequence F description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 34) chain A residue 262 type sequence W description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 35) chain A residue 276 type sequence I description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 36) chain A residue 281 type sequence K description BINDING SITE FOR RESIDUE GOL A 796 source : AC6 37) chain A residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000250|UniProtKB:P48147 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 157 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P48147 source Swiss-Prot : SWS_FT_FI5 39) chain A residue 473 type catalytic sequence F description 901 source MCSA : MCSA1 40) chain A residue 554 type catalytic sequence S description 901 source MCSA : MCSA1 41) chain A residue 641 type catalytic sequence D description 901 source MCSA : MCSA1 42) chain A residue 680 type catalytic sequence H description 901 source MCSA : MCSA1 43) chain A residue 554 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084, ECO:0000269|PubMed:1900195 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 641 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI2 45) chain A residue 680 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084, ECO:0000269|PubMed:2064618 source Swiss-Prot : SWS_FT_FI3 46) chain A residue 529-559 type prosite sequence DFQCAAEYLIKEGYTSPKRLTINGGSNGGLL description PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DfqcAaeyLikegytspkrltinGgSnGGLL source prosite : PS00708

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