eF-site ID 1h2u-ABXY PDB Code 1h2u Chain A, B, X, Y click to enlarge Title Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG Classification NUCLEAR PROTEIN Compound 80 KDA NUCLEAR CAP BINDING PROTEIN Source (CB20_HUMAN) Sequence A:  ETEDHLESLICKVGEKSACSLESNLEGLAGVLEADLPNYK SKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGGEFV EAMIRQLKESLKANNYNEAVYLVRFLSDLVNCHVIAAPSM VAMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWVGKELY EKKDAEMDRIFANTESYLKRRQKTHVPMLQVWTADKPHPQ EEYLDCLWAQIQKLKKDRWQERHILRPYLAFDSILCEALQ HNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPG SHSVERFVIEENLHCIIKSHWKERKTCAAQLVSYPGKNKI PLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPG SLPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQ FRWSWEDWSDCLSQDPESPKPKFVREVLEKCMRLSYHQRI LDIVPPTFSALCPSNPTCIYKYGDESSNSLPGHSVALCLA VAFKSKATNDEIFSILKDVPNPFNPLKIEVFVQTLLHLAA KSFSHSFSALAKFHEVFKTLAESDEGKLHVLRVMFEVWRN HPQMIAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLF VWEILHSTIRKMNKHVGAQSEQKNLFLVIFQRFIMILTEH LVRCETDGTSVLTPWYKNCIERLQQIFLQHHQIIQQYMVT LENLLFTAELDPHILAVFQQFCALQA B:  TEDHLESLICKVGEKSACSLESNLEGLAGVLEADLPNYKS KILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGGEFVE AMIRQLKESLKANNYNEAVYLVRFLSDLVNCHVIAAPSMV AMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWVGKELYE KKDAEMDRIFANTESYLKRRQKTHVPMLQVWTADKPHPQE EYLDCLWAQIQKLKKDRWQERHILRPYLAFDSILCEALQH NLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPGS HSVERFVIEENLHCIIKSHWKERKTCAAQLVSYPGKNKIP LNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPGS LPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQF RWSWEDWSDCLSQDPESPKPKFVREVLEKCMRLSYHQRIL DIVPPTFSALCPSNPTCIYKYGDESSNSLPGHSVALCLAV AFKSKATNDEIFSILKDVPNPSFNPLKIEVFVQTLLHLAA KSFSHSFSALAKFHEVFKTLAESDEGKLHVLRVMFEVWRN HPQMIAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLF VWEILHSTIRKMNKHVGAQSEQKNLFLVIFQRFIMILTEH LVRCETDGTSVLTPWYKNCIERLQQIFLQHHQIIQQYMVT LENLLFTAELDPHILAVFQQFCALQA X:  GLLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLY VGNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGF CFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFKEGR QYGRGRSGGQVRDEYRQDYDAGRGGYGKL Y:  LLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLYV GNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGFC FVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFKEGRQ YGRGRSGGQVRDEYRQDYDAGRGGYGK Description Functional site 1) chain X residue 20 type sequence Y description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 2) chain X residue 127 type sequence R description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 3) chain X residue 134 type sequence V description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 4) chain X residue 135 type sequence R description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 5) chain Y residue 19 type sequence Q description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 6) chain Y residue 21 type sequence R description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 7) chain Y residue 23 type sequence Q description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 8) chain Y residue 29 type sequence N description BINDING SITE FOR RESIDUE GDP X1153 source : AC1 9) chain X residue 20 type sequence Y description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 10) chain X residue 22 type sequence D description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 11) chain X residue 43 type sequence Y description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 12) chain X residue 83 type sequence F description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 13) chain X residue 112 type sequence R description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 14) chain X residue 114 type sequence D description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 15) chain X residue 115 type sequence W description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 16) chain X residue 116 type sequence D description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 17) chain X residue 123 type sequence R description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 18) chain X residue 125 type sequence Y description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 19) chain X residue 126 type sequence G description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 20) chain X residue 127 type sequence R description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 21) chain X residue 133 type sequence Q description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 22) chain X residue 134 type sequence V description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 23) chain X residue 135 type sequence R description BINDING SITE FOR RESIDUE 7MG X1154 source : AC2 24) chain X residue 23 type sequence Q description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 25) chain X residue 25 type sequence F description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 26) chain X residue 27 type sequence G description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 27) chain Y residue 20 type sequence Y description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 28) chain Y residue 127 type sequence R description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 29) chain Y residue 134 type sequence V description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 30) chain Y residue 135 type sequence R description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 31) chain Y residue 138 type sequence Y description BINDING SITE FOR RESIDUE GDP Y1152 source : AC3 32) chain Y residue 20 type sequence Y description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 33) chain Y residue 43 type sequence Y description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 34) chain Y residue 83 type sequence F description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 35) chain Y residue 112 type sequence R description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 36) chain Y residue 114 type sequence D description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 37) chain Y residue 115 type sequence W description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 38) chain Y residue 116 type sequence D description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 39) chain Y residue 123 type sequence R description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 40) chain Y residue 125 type sequence Y description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 41) chain Y residue 126 type sequence G description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 42) chain Y residue 127 type sequence R description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 43) chain Y residue 133 type sequence Q description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 44) chain Y residue 134 type sequence V description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 45) chain Y residue 135 type sequence R description BINDING SITE FOR RESIDUE 7MG Y1153 source : AC4 46) chain X residue 18 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI5 47) chain Y residue 18 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI5 48) chain B residue 732 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI5 49) chain X residue 20 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151 source Swiss-Prot : SWS_FT_FI1 50) chain X residue 43 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151 source Swiss-Prot : SWS_FT_FI1 51) chain Y residue 20 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151 source Swiss-Prot : SWS_FT_FI1 52) chain Y residue 43 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151 source Swiss-Prot : SWS_FT_FI1 53) chain X residue 112 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 54) chain X residue 123 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 55) chain X residue 133 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 56) chain Y residue 112 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 57) chain Y residue 123 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 58) chain Y residue 133 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 59) chain X residue 13 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 60) chain Y residue 13 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 61) chain B residue 204 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 62) chain B residue 746 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 63) chain X residue 146 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI6 64) chain Y residue 146 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI6

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