eF-site ID 1h2t-Z
PDB Code 1h2t
Chain Z

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Title Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Classification NUCLEAR PROTEIN
Compound 80 KDA NUCLEAR CAP BINDING PROTEIN
Source (CB20_HUMAN)
Sequence Z:  LLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLYV
GNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGFC
FVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFKEGRQ
YGRGRSGGQVRDEYRQDYDAGRGGYG
Description


Functional site

1) chain Z
residue 20
type
sequence Y
description BINDING SITE FOR RESIDUE GDP Z1151
source : AC1

2) chain Z
residue 127
type
sequence R
description BINDING SITE FOR RESIDUE GDP Z1151
source : AC1

3) chain Z
residue 134
type
sequence V
description BINDING SITE FOR RESIDUE GDP Z1151
source : AC1

4) chain Z
residue 138
type
sequence Y
description BINDING SITE FOR RESIDUE GDP Z1151
source : AC1

5) chain Z
residue 20
type
sequence Y
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

6) chain Z
residue 22
type
sequence D
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

7) chain Z
residue 43
type
sequence Y
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

8) chain Z
residue 83
type
sequence F
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

9) chain Z
residue 112
type
sequence R
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

10) chain Z
residue 114
type
sequence D
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

11) chain Z
residue 115
type
sequence W
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

12) chain Z
residue 116
type
sequence D
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

13) chain Z
residue 123
type
sequence R
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

14) chain Z
residue 125
type
sequence Y
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

15) chain Z
residue 127
type
sequence R
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

16) chain Z
residue 133
type
sequence Q
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

17) chain Z
residue 134
type
sequence V
description BINDING SITE FOR RESIDUE 7MG Z1152
source : AC2

18) chain Z
residue 18
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:17525332
source Swiss-Prot : SWS_FT_FI5

19) chain Z
residue 112
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI2

20) chain Z
residue 123
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI2

21) chain Z
residue 133
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI2

22) chain Z
residue 13
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

23) chain Z
residue 20
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151
source Swiss-Prot : SWS_FT_FI1

24) chain Z
residue 43
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12374755, ECO:0000269|PubMed:12434151
source Swiss-Prot : SWS_FT_FI1

25) chain Z
residue 146
type MOD_RES
sequence R
description Omega-N-methylarginine => ECO:0007744|PubMed:24129315
source Swiss-Prot : SWS_FT_FI6


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