eF-site ID 1h2n-A PDB Code 1h2n Chain A click to enlarge Title Factor Inhibiting HIF-1 alpha Classification OXIDOREDUCTASE Compound HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR Source null (HIF1N_HUMAN) Sequence A:  EPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEE LIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYS ASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQD IQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQ GKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYK RCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPN FQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVN FWYKGAPTPEYPLKAHQKVAIMRNIEKMLGEALGNPQEVG PLLNTMIKGRYN Description (1)  HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (E.C.1.14.11.16) Functional site 1) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE FE2 A 1350 source : AC1 2) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE FE2 A 1350 source : AC1 3) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE FE2 A 1350 source : AC1 4) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC2 5) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC2 6) chain A residue 141 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC2 7) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC2 8) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC3 9) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC3 10) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC3 11) chain A residue 285 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC3 12) chain A residue 286 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC3 13) chain A residue 107 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC4 14) chain A residue 202 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC4 15) chain A residue 320 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC4 16) chain A residue 324 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC4 17) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 18) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 19) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 20) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 21) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 22) chain A residue 205 type sequence N description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 23) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 24) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 25) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 26) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 27) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 28) chain A residue 296 type sequence W description BINDING SITE FOR RESIDUE AKG A 1351 source : AC5 29) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 214 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 145 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 181 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 300 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 152 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 279 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 199 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 41) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 340 type SITE sequence L description Important for dimer formation source Swiss-Prot : SWS_FT_FI4

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