eF-site ID 1h16-A PDB Code 1h16 Chain A click to enlarge Title Pyruvate Formate-Lyase (E.coli) in complex with Pyruvate and CoA Classification TRANSFERASE Compound FORMATE ACETYLTRANSFERASE 1 Source ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; Sequence A:  SELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDE SFLAGATEATTTLWDKVMEGVKLENRTHAPVDFDTAVAST ITSHDAGYINKQLEKIVGLQTEAPLKRALIPFGGIKMIEG SCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYTPDILRCR KSGVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQF TSLQADLENGVNLEQTIRLREEIAEQHRALGQMKEMAAKY GYDISGPATNAQEAIQWTYFGYLAAVKSQNGAAMSFGRTS TFLDVYIERDLKAGKITEQEAQEMVDHLVMKLRMVRFLRT PEYDELFSGDPIWATESIGGMGLDGRTLVTKNSFRFLNTL YTMGPSPEPNMTILWSEKLPLNFKKFAAKVSIDTSSLQYE NDDLMRPDFNNDDYAIACCVSPMIVGKQMQFFGARANLAK TMLYAINGGVDEKLKMQVGPKSEPIKGDVLNYDEVMERMD HFMDWLAKQYITALNIIHYMHDKYSYEASLMALHDRDVIR TMACGIAGLSVAADSLSAIKYAKVKPIRDEDGLAIDFEIE GEYPQFGNNDPRVDDLAVDLVERFMKKIQKLHTYRDAIPT QSVLTITSNVVYGKKTGNTPDGRRAGAPFGPGANPMHGRD QKGAVASLTSVAKLPFAYAKDGISYTFSIVPNALGKDDEV RKTNLAGLMDGYFHHEASIEGGQHLNVNVMNREMLLDAME NPEKYPQLTIRVSGYAVRFNSLTKEQQQDVITRTFTQSM Description Functional site 1) chain A residue 652 type sequence A description BINDING SITE FOR RESIDUE NA A 9001 source : AC1 2) chain A residue 654 type sequence L description BINDING SITE FOR RESIDUE NA A 9001 source : AC1 3) chain A residue 700 type sequence E description BINDING SITE FOR RESIDUE NA A 9001 source : AC1 4) chain A residue 701 type sequence G description BINDING SITE FOR RESIDUE NA A 9001 source : AC1 5) chain A residue 214 type sequence E description BINDING SITE FOR RESIDUE NA A 9002 source : AC2 6) chain A residue 215 type sequence Q description BINDING SITE FOR RESIDUE NA A 9002 source : AC2 7) chain A residue 218 type sequence R description BINDING SITE FOR RESIDUE NA A 9002 source : AC2 8) chain A residue 80 type sequence T description BINDING SITE FOR RESIDUE NA A 9003 source : AC3 9) chain A residue 81 type sequence I description BINDING SITE FOR RESIDUE NA A 9003 source : AC3 10) chain A residue 268 type sequence S description BINDING SITE FOR RESIDUE NA A 9003 source : AC3 11) chain A residue 589 type sequence Q description BINDING SITE FOR RESIDUE NA A 9005 source : AC5 12) chain A residue 599 type sequence P description BINDING SITE FOR RESIDUE NA A 9005 source : AC5 13) chain A residue 62 type sequence K description BINDING SITE FOR RESIDUE NA A 9006 source : AC6 14) chain A residue 112 type sequence F description BINDING SITE FOR RESIDUE NA A 9007 source : AC7 15) chain A residue 116 type sequence K description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 16) chain A residue 117 type sequence M description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 17) chain A residue 145 type sequence N description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 18) chain A residue 146 type sequence Q description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 19) chain A residue 149 type sequence F description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 20) chain A residue 150 type sequence D description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 21) chain A residue 152 type sequence Y description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 22) chain A residue 160 type sequence R description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 23) chain A residue 161 type sequence K description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 24) chain A residue 200 type sequence F description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 25) chain A residue 227 type sequence H description BINDING SITE FOR RESIDUE COA A 1000 source : AC9 26) chain A residue 176 type sequence R description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 27) chain A residue 273 type sequence A description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 28) chain A residue 418 type sequence C description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 29) chain A residue 432 type sequence F description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 30) chain A residue 435 type sequence R description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 31) chain A residue 604 type sequence L description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 32) chain A residue 606 type sequence I description BINDING SITE FOR RESIDUE PYR A 1001 source : BC1 33) chain A residue 138 type sequence T description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 34) chain A residue 139 type sequence E description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 35) chain A residue 142 type sequence K description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 36) chain A residue 225 type sequence E description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 37) chain A residue 228 type sequence R description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 38) chain A residue 232 type sequence Q description BINDING SITE FOR RESIDUE DTL A 9009 source : BC2 39) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 40) chain A residue 70 type sequence P description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 41) chain A residue 125 type sequence Y description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 42) chain A residue 324 type sequence D description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 43) chain A residue 330 type sequence D description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 44) chain A residue 741 type sequence S description BINDING SITE FOR RESIDUE DTL A 9010 source : BC3 45) chain A residue 40 type sequence E description BINDING SITE FOR RESIDUE PG4 A 9011 source : BC4 46) chain A residue 198 type sequence A description BINDING SITE FOR RESIDUE PG4 A 9012 source : BC5 47) chain A residue 199 type sequence Q description BINDING SITE FOR RESIDUE PG4 A 9012 source : BC5 48) chain A residue 202 type sequence S description BINDING SITE FOR RESIDUE PG4 A 9012 source : BC5 49) chain A residue 516 type sequence R description BINDING SITE FOR RESIDUE PG4 A 9012 source : BC5 50) chain A residue 517 type sequence D description BINDING SITE FOR RESIDUE PG4 A 9012 source : BC5 51) chain A residue 648 type sequence L description BINDING SITE FOR RESIDUE PG4 A 9013 source : BC6 52) chain A residue 649 type sequence T description BINDING SITE FOR RESIDUE PG4 A 9013 source : BC6 53) chain A residue 688 type sequence L description BINDING SITE FOR RESIDUE PG4 A 9013 source : BC6 54) chain A residue 691 type sequence G description BINDING SITE FOR RESIDUE PG4 A 9013 source : BC6 55) chain A residue 692 type sequence Y description BINDING SITE FOR RESIDUE PG4 A 9013 source : BC6 56) chain A residue 334 type catalytic sequence A description 30 source MCSA : MCSA1 57) chain A residue 419 type catalytic sequence C description 30 source MCSA : MCSA1 58) chain A residue 420 type catalytic sequence V description 30 source MCSA : MCSA1 59) chain A residue 735 type catalytic sequence Y description 30 source MCSA : MCSA1 60) chain A residue 729-737 type prosite sequence TIRVSGYAV description GLY_RADICAL_1 Glycine radical domain signature. TiRVSGYAV source prosite : PS00850 61) chain A residue 419 type ACT_SITE sequence C description S-acetylcysteine intermediate => ECO:0000269|PubMed:1310545 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 420 type ACT_SITE sequence V description Cysteine radical intermediate => ECO:0000269|PubMed:1310545 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 63 type MOD_RES sequence L description N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI3 64) chain A residue 117 type MOD_RES sequence M description N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 195 type MOD_RES sequence D description N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI3 66) chain A residue 454 type MOD_RES sequence L description N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 107 type MOD_RES sequence R description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI4 68) chain A residue 124 type MOD_RES sequence A description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI4 69) chain A residue 467 type MOD_RES sequence G description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI4 70) chain A residue 654 type MOD_RES sequence L description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI4 71) chain A residue 541 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI5 72) chain A residue 591 type MOD_RES sequence L description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI5 73) chain A residue 735 type MOD_RES sequence Y description Glycine radical => ECO:0000269|PubMed:1310545 source Swiss-Prot : SWS_FT_FI6

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