eF-site ID 1h15-D
PDB Code 1h15
Chain D

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Title X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase
Classification IMMUNE SYSTEM/TRANSFERASE
Compound HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
Source Homo sapiens (Human) (DPOL_EBV)
Sequence D:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWEFDA
Description


Functional site

1) chain D
residue 49
type SITE
sequence G
description Self-peptide antigen => ECO:0000269|PubMed:31619516
source Swiss-Prot : SWS_FT_FI2

2) chain D
residue 52
type SITE
sequence A
description Self-peptide antigen => ECO:0000269|PubMed:31619516
source Swiss-Prot : SWS_FT_FI2

3) chain D
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI5

4) chain D
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6

5) chain D
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7

6) chain D
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8

7) chain D
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI9

8) chain D
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI9

9) chain D
residue 51
type SITE
sequence F
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3

10) chain D
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI4


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