eF-site/Summary 1h15-ABCDEF

eF-site ID	1h15-ABCDEF
PDB Code	1h15
Chain	A, B, C, D, E, F

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Title	X-ray crystal structure of HLA-DRA10101/DRB50101 complexed with a peptide from Epstein Barr Virus DNA polymerase
Classification	IMMUNE SYSTEM/TRANSFERASE
Compound	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
Source	null (DPOL_EBV)

Sequence	A:	EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEFDA
	B:	DTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFD SDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRH NYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNG FYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVML ETVPRSGEVYTCQVEHPSVTSPLTVEWRA
	C:	GGVYHFVKKHVHES
	D:	EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEFDA
	E:	DTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFD SDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRH NYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNG FYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVML ETVPRSGEVYTCQVEHPSVTSPLTVEWRA
	F:	GGVYHFVKKHVHES

Description

Functional site


1)	chain	A
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI5

2)	chain	D
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI5

3)	chain	A
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

4)	chain	D
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

5)	chain	A
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

6)	chain	D
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

7)	chain	A
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

8)	chain	D
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

9)	chain	A
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

10)	chain	A
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

11)	chain	D
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

12)	chain	D
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

13)	chain	B
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218
	source	Swiss-Prot : SWS_FT_FI1

14)	chain	E
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218
	source	Swiss-Prot : SWS_FT_FI1

15)	chain	A
	residue	49
	type	SITE
	sequence	G
	description	Self-peptide antigen => ECO:0000269\|PubMed:31619516
	source	Swiss-Prot : SWS_FT_FI2

16)	chain	A
	residue	52
	type	SITE
	sequence	A
	description	Self-peptide antigen => ECO:0000269\|PubMed:31619516
	source	Swiss-Prot : SWS_FT_FI2

17)	chain	D
	residue	49
	type	SITE
	sequence	G
	description	Self-peptide antigen => ECO:0000269\|PubMed:31619516
	source	Swiss-Prot : SWS_FT_FI2

18)	chain	D
	residue	52
	type	SITE
	sequence	A
	description	Self-peptide antigen => ECO:0000269\|PubMed:31619516
	source	Swiss-Prot : SWS_FT_FI2

19)	chain	A
	residue	51
	type	SITE
	sequence	F
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

20)	chain	D
	residue	51
	type	SITE
	sequence	F
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

21)	chain	A
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI4

22)	chain	D
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI4

23)	chain	B
	residue	171-177
	type	prosite
	sequence	YTCQVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
	source	prosite : PS00290

24)	chain	A
	residue	161-167
	type	prosite
	sequence	YDCRVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
	source	prosite : PS00290