eF-site ID 1gvk-B PDB Code 1gvk Chain B click to enlarge Title Porcine pancreatic elastase acyl enzyme at 0.95 A resolution Classification HYDROLASE/HYDROLASE INHIBITOR Compound PEPTIDE INHIBITOR Source ORGANISM_COMMON: PIG; ORGANISM_SCIENTIFIC: SUS SCROFA; Sequence B:  VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWV MTAAHCVDRELTFRVVVGEHNLNQNNGTEQYVGVQKIVVH PYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTI LANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSS SSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQY AVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN Description Functional site 1) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE CA B 1246 source : AC1 2) chain B residue 72 type sequence N description BINDING SITE FOR RESIDUE CA B 1246 source : AC1 3) chain B residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA B 1246 source : AC1 4) chain B residue 77 type sequence N description BINDING SITE FOR RESIDUE CA B 1246 source : AC1 5) chain B residue 80 type sequence E description BINDING SITE FOR RESIDUE CA B 1246 source : AC1 6) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1247 source : AC2 7) chain B residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1247 source : AC2 8) chain B residue 230 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1247 source : AC2 9) chain B residue 232 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1247 source : AC2 10) chain B residue 233 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1247 source : AC2 11) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1248 source : AC3 12) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1248 source : AC3 13) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1248 source : AC3 14) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1248 source : AC3 15) chain B residue 57 type sequence H description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 16) chain B residue 62 type sequence E description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 17) chain B residue 190 type sequence G description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 18) chain B residue 191 type sequence C description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 19) chain B residue 192 type sequence Q description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 20) chain B residue 193 type sequence G description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 21) chain B residue 194 type sequence D description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 22) chain B residue 195 type sequence S description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 23) chain B residue 213 type sequence T description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 24) chain B residue 214 type sequence S description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 25) chain B residue 215 type sequence F description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 26) chain B residue 216 type sequence V description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 27) chain B residue 217 type sequence S description BINDING SITE FOR CHAIN A OF PEPTIDE INHIBITOR source : AC4 28) chain B residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:4578945, ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 70 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 30) chain B residue 72 type BINDING sequence N description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 31) chain B residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 32) chain B residue 80 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 33) chain B residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 53-58 type prosite sequence MTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC source prosite : PS00134 36) chain B residue 189-200 type prosite sequence SGCQGDSGGPLH description TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH source prosite : PS00135

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