eF-site ID 1gtb-A PDB Code 1gtb Chain A click to enlarge Title CRYSTAL STRUCTURES OF A SCHISTOSOMAL DRUG AND VACCINE TARGET: GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA AND ITS COMPLEX WITH THE LEADING ANTISCHISTOSOMAL DRUG PRAZIQUANTEL Classification GLUTATHIONE TRANSFERASE Compound GLUTATHIONE S-TRANSFERASE Source Schistosoma japonicum (Blood fluke) (GST26_SCHJA) Sequence A:  MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDK WRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHN MLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKV DFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALD VVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPK Description Functional site 1) chain A residue 67 type sequence Q description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 2) chain A residue 97 type sequence G description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 3) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 4) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 5) chain A residue 104 type sequence Y description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 6) chain A residue 104 type sequence Y description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 7) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 8) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE PZQ A 901 source : AC1 9) chain A residue 7 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 41 type BINDING sequence W description BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 54 type BINDING sequence N description BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 67 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 111 type BINDING sequence Y description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2

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