|
|
eF-site ID
|
1gko-C |
|
PDB Code
|
1gko |
|
Chain
|
C |
|
click to enlarge
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Title
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An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured |
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Classification
|
TRANSPORT(THYROXINE) |
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Compound
|
TRANSTHYRETIN |
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Source
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(TTHY_HUMAN) |
|
|
Sequence
|
C: |
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKT
SESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHE
HAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTN
|
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|
Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
15 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
C |
| residue |
54 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
C |
| residue |
117 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
C |
| residue |
10 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
C |
| residue |
42 |
| type |
MOD_RES |
| sequence |
E
|
| description |
4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
C |
| residue |
52 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P02767
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
C |
| residue |
98 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|