eF-site ID 1gkd-AB PDB Code 1gkd Chain A, B click to enlarge Title MMP9 active site mutant-inhibitor complex Classification HYDROLASE Compound 92 KDA TYPE IV COLLAGENASE Source null (MM09_HUMAN) Sequence A:  FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWS AVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLA HAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFG HALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY B:  LKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTP LTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFP PGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALG LDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY Description Functional site 1) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A1444 source : AC1 2) chain A residue 183 type sequence G description BINDING SITE FOR RESIDUE CA A1444 source : AC1 3) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE CA A1444 source : AC1 4) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE CA A1444 source : AC1 5) chain A residue 205 type sequence D description BINDING SITE FOR RESIDUE CA A1444 source : AC1 6) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A1444 source : AC1 7) chain A residue 165 type sequence D description BINDING SITE FOR RESIDUE CA A1445 source : AC2 8) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE CA A1445 source : AC2 9) chain A residue 199 type sequence Q description BINDING SITE FOR RESIDUE CA A1445 source : AC2 10) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE CA A1445 source : AC2 11) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE CA A1446 source : AC3 12) chain A residue 206 type sequence D description BINDING SITE FOR RESIDUE CA A1446 source : AC3 13) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A1446 source : AC3 14) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE CA A1447 source : AC4 15) chain A residue 212 type sequence L description BINDING SITE FOR RESIDUE CA A1447 source : AC4 16) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE CA A1447 source : AC4 17) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE CA A1447 source : AC4 18) chain A residue 215 type sequence G description BINDING SITE FOR RESIDUE CA A1447 source : AC4 19) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE ZN A1450 source : AC5 20) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE ZN A1450 source : AC5 21) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE ZN A1450 source : AC5 22) chain A residue 175 type sequence H description BINDING SITE FOR RESIDUE ZN A1451 source : AC6 23) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE ZN A1451 source : AC6 24) chain A residue 190 type sequence H description BINDING SITE FOR RESIDUE ZN A1451 source : AC6 25) chain A residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN A1451 source : AC6 26) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE CA B1444 source : AC7 27) chain B residue 183 type sequence G description BINDING SITE FOR RESIDUE CA B1444 source : AC7 28) chain B residue 185 type sequence D description BINDING SITE FOR RESIDUE CA B1444 source : AC7 29) chain B residue 187 type sequence L description BINDING SITE FOR RESIDUE CA B1444 source : AC7 30) chain B residue 205 type sequence D description BINDING SITE FOR RESIDUE CA B1444 source : AC7 31) chain B residue 208 type sequence E description BINDING SITE FOR RESIDUE CA B1444 source : AC7 32) chain B residue 165 type sequence D description BINDING SITE FOR RESIDUE CA B1445 source : AC8 33) chain B residue 197 type sequence G description BINDING SITE FOR RESIDUE CA B1445 source : AC8 34) chain B residue 199 type sequence Q description BINDING SITE FOR RESIDUE CA B1445 source : AC8 35) chain B residue 201 type sequence D description BINDING SITE FOR RESIDUE CA B1445 source : AC8 36) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE CA B1446 source : AC9 37) chain B residue 206 type sequence D description BINDING SITE FOR RESIDUE CA B1446 source : AC9 38) chain B residue 208 type sequence E description BINDING SITE FOR RESIDUE CA B1446 source : AC9 39) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE CA B1447 source : BC1 40) chain B residue 212 type sequence L description BINDING SITE FOR RESIDUE CA B1447 source : BC1 41) chain B residue 213 type sequence G description BINDING SITE FOR RESIDUE CA B1447 source : BC1 42) chain B residue 214 type sequence K description BINDING SITE FOR RESIDUE CA B1447 source : BC1 43) chain B residue 215 type sequence G description BINDING SITE FOR RESIDUE CA B1447 source : BC1 44) chain B residue 401 type sequence H description BINDING SITE FOR RESIDUE ZN B1450 source : BC2 45) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE ZN B1450 source : BC2 46) chain B residue 411 type sequence H description BINDING SITE FOR RESIDUE ZN B1450 source : BC2 47) chain B residue 175 type sequence H description BINDING SITE FOR RESIDUE ZN B1451 source : BC3 48) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE ZN B1451 source : BC3 49) chain B residue 190 type sequence H description BINDING SITE FOR RESIDUE ZN B1451 source : BC3 50) chain B residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN B1451 source : BC3 51) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE STN A1448 source : BC4 52) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE STN A1448 source : BC4 53) chain A residue 189 type sequence A description BINDING SITE FOR RESIDUE STN A1448 source : BC4 54) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE STN A1448 source : BC4 55) chain A residue 402 type sequence Q description BINDING SITE FOR RESIDUE STN A1448 source : BC4 56) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE STN A1448 source : BC4 57) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE STN A1448 source : BC4 58) chain A residue 423 type sequence Y description BINDING SITE FOR RESIDUE STN A1448 source : BC4 59) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE BUM A1449 source : BC5 60) chain A residue 393 type sequence Y description BINDING SITE FOR RESIDUE BUM A1449 source : BC5 61) chain A residue 421 type sequence P description BINDING SITE FOR RESIDUE BUM A1449 source : BC5 62) chain A residue 423 type sequence Y description BINDING SITE FOR RESIDUE BUM A1449 source : BC5 63) chain B residue 187 type sequence L description BINDING SITE FOR RESIDUE STN B1448 source : BC6 64) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE STN B1448 source : BC6 65) chain B residue 189 type sequence A description BINDING SITE FOR RESIDUE STN B1448 source : BC6 66) chain B residue 402 type sequence Q description BINDING SITE FOR RESIDUE STN B1448 source : BC6 67) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE STN B1448 source : BC6 68) chain B residue 411 type sequence H description BINDING SITE FOR RESIDUE STN B1448 source : BC6 69) chain B residue 422 type sequence M description BINDING SITE FOR RESIDUE STN B1448 source : BC6 70) chain B residue 423 type sequence Y description BINDING SITE FOR RESIDUE STN B1448 source : BC6 71) chain B residue 186 type sequence G description BINDING SITE FOR RESIDUE BUM B1449 source : BC7 72) chain B residue 421 type sequence P description BINDING SITE FOR RESIDUE BUM B1449 source : BC7 73) chain B residue 423 type sequence Y description BINDING SITE FOR RESIDUE BUM B1449 source : BC7 74) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 75) chain A residue 205 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 76) chain A residue 206 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 77) chain A residue 208 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 78) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 79) chain B residue 165 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 80) chain B residue 182 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 81) chain B residue 183 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 82) chain B residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 83) chain B residue 187 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 84) chain B residue 197 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 85) chain B residue 199 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 86) chain B residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 87) chain B residue 205 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 88) chain B residue 206 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 208 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 90) chain A residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 91) chain A residue 187 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 92) chain A residue 197 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 93) chain A residue 199 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 94) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 95) chain A residue 165 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 182 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 183 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 98) chain A residue 175 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 99) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 100) chain A residue 190 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 101) chain B residue 190 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 102) chain B residue 203 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 103) chain B residue 175 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 104) chain B residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 105) chain A residue 203 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 106) chain A residue 120 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 107) chain A residue 127 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 108) chain B residue 120 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 109) chain B residue 127 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

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