eF-site ID 1gkc-AB PDB Code 1gkc Chain A, B click to enlarge Title MMP9-inhibitor complex Classification HYDROLASE/HYDROLASE INHIBITOR Compound 92 KDA TYPE IV COLLAGENASE Source Homo sapiens (Human) (MM09_HUMAN) Sequence A:  FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWS AVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLA HAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHEFG HALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY B:  DLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVT PLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAF PPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHEFGHAL GLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY Description Functional site 1) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 2) chain A residue 183 type sequence G description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 3) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 4) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 5) chain A residue 205 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 6) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 7) chain A residue 165 type sequence D description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 8) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 9) chain A residue 199 type sequence Q description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 10) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 11) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 12) chain A residue 206 type sequence D description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 13) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 14) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 15) chain A residue 212 type sequence L description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 16) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 17) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 18) chain A residue 215 type sequence G description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 19) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 20) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 21) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 22) chain A residue 189 type sequence A description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 23) chain A residue 393 type sequence Y description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 24) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 25) chain A residue 402 type sequence E description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 26) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 27) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 28) chain A residue 421 type sequence P description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 29) chain A residue 422 type sequence M description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 30) chain A residue 423 type sequence Y description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 31) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 32) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 33) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 34) chain A residue 175 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 35) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 36) chain A residue 190 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 37) chain A residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 38) chain A residue 149 type sequence S description BINDING SITE FOR RESIDUE CA A 1452 source : AC8 39) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 40) chain B residue 183 type sequence G description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 41) chain B residue 185 type sequence D description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 42) chain B residue 187 type sequence L description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 43) chain B residue 205 type sequence D description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 44) chain B residue 208 type sequence E description BINDING SITE FOR RESIDUE CA B 1444 source : AC9 45) chain B residue 165 type sequence D description BINDING SITE FOR RESIDUE CA B 1445 source : BC1 46) chain B residue 197 type sequence G description BINDING SITE FOR RESIDUE CA B 1445 source : BC1 47) chain B residue 199 type sequence Q description BINDING SITE FOR RESIDUE CA B 1445 source : BC1 48) chain B residue 201 type sequence D description BINDING SITE FOR RESIDUE CA B 1445 source : BC1 49) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE CA B 1446 source : BC2 50) chain B residue 206 type sequence D description BINDING SITE FOR RESIDUE CA B 1446 source : BC2 51) chain B residue 208 type sequence E description BINDING SITE FOR RESIDUE CA B 1446 source : BC2 52) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE CA B 1447 source : BC3 53) chain B residue 212 type sequence L description BINDING SITE FOR RESIDUE CA B 1447 source : BC3 54) chain B residue 213 type sequence G description BINDING SITE FOR RESIDUE CA B 1447 source : BC3 55) chain B residue 214 type sequence K description BINDING SITE FOR RESIDUE CA B 1447 source : BC3 56) chain B residue 391 type sequence Q description BINDING SITE FOR RESIDUE CA B 1447 source : BC3 57) chain B residue 149 type sequence S description BINDING SITE FOR RESIDUE CA B 1448 source : BC4 58) chain B residue 152 type sequence T description BINDING SITE FOR RESIDUE CA B 1448 source : BC4 59) chain B residue 186 type sequence G description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 60) chain B residue 187 type sequence L description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 61) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 62) chain B residue 189 type sequence A description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 63) chain B residue 393 type sequence Y description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 64) chain B residue 401 type sequence H description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 65) chain B residue 402 type sequence E description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 66) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 67) chain B residue 411 type sequence H description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 68) chain B residue 420 type sequence Y description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 69) chain B residue 421 type sequence P description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 70) chain B residue 422 type sequence M description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 71) chain B residue 423 type sequence Y description BINDING SITE FOR RESIDUE NFH B 1449 source : BC5 72) chain B residue 401 type sequence H description BINDING SITE FOR RESIDUE ZN B 1451 source : BC6 73) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE ZN B 1451 source : BC6 74) chain B residue 411 type sequence H description BINDING SITE FOR RESIDUE ZN B 1451 source : BC6 75) chain B residue 175 type sequence H description BINDING SITE FOR RESIDUE ZN B 1452 source : BC7 76) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE ZN B 1452 source : BC7 77) chain B residue 190 type sequence H description BINDING SITE FOR RESIDUE ZN B 1452 source : BC7 78) chain B residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN B 1452 source : BC7 79) chain A residue 398-407 type prosite sequence VAAHEFGHAL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL source prosite : PS00142 80) chain A residue 402 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 402 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI1 82) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 83) chain A residue 205 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 206 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 85) chain A residue 208 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 86) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 87) chain B residue 165 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 88) chain B residue 182 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 183 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 90) chain B residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 91) chain B residue 187 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 197 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 93) chain A residue 165 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 199 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 205 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 206 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 208 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 182 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 183 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 101) chain A residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 102) chain A residue 187 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 103) chain A residue 197 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 199 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 175 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 107) chain B residue 190 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 108) chain B residue 203 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 109) chain B residue 401 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 110) chain B residue 405 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 111) chain B residue 411 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 112) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 113) chain A residue 190 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 114) chain A residue 203 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 115) chain A residue 401 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 116) chain A residue 405 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 117) chain A residue 411 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 118) chain B residue 175 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 119) chain B residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 120) chain A residue 120 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 121) chain A residue 127 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 122) chain B residue 120 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 123) chain B residue 127 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links