eF-site ID 1gkc-A PDB Code 1gkc Chain A click to enlarge Title MMP9-inhibitor complex Classification HYDROLASE/HYDROLASE INHIBITOR Compound 92 KDA TYPE IV COLLAGENASE Source null (MM09_HUMAN) Sequence A:  FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWS AVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLA HAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHEFG HALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY Description Functional site 1) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 2) chain A residue 183 type sequence G description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 3) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 4) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 5) chain A residue 205 type sequence D description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 6) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A 1444 source : AC1 7) chain A residue 165 type sequence D description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 8) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 9) chain A residue 199 type sequence Q description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 10) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE CA A 1445 source : AC2 11) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 12) chain A residue 206 type sequence D description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 13) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE CA A 1446 source : AC3 14) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 15) chain A residue 212 type sequence L description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 16) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 17) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 18) chain A residue 215 type sequence G description BINDING SITE FOR RESIDUE CA A 1447 source : AC4 19) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 20) chain A residue 187 type sequence L description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 21) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 22) chain A residue 189 type sequence A description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 23) chain A residue 393 type sequence Y description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 24) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 25) chain A residue 402 type sequence E description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 26) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 27) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 28) chain A residue 421 type sequence P description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 29) chain A residue 422 type sequence M description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 30) chain A residue 423 type sequence Y description BINDING SITE FOR RESIDUE NFH A 1448 source : AC5 31) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 32) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 33) chain A residue 411 type sequence H description BINDING SITE FOR RESIDUE ZN A 1450 source : AC6 34) chain A residue 175 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 35) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 36) chain A residue 190 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 37) chain A residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN A 1451 source : AC7 38) chain A residue 149 type sequence S description BINDING SITE FOR RESIDUE CA A 1452 source : AC8 39) chain A residue 402 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 165 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 182 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 183 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 205 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 206 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 208 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 187 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 197 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 199 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 175 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 53) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 54) chain A residue 190 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 55) chain A residue 203 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 56) chain A residue 401 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 57) chain A residue 405 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 58) chain A residue 411 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12051944, ECO:0000269|PubMed:12077439 source Swiss-Prot : SWS_FT_FI3 59) chain A residue 398-407 type prosite sequence VAAHEFGHAL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL source prosite : PS00142 60) chain A residue 120 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 61) chain A residue 127 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

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