|
eF-site ID
|
1gjh-A |
PDB Code
|
1gjh |
Chain
|
A |
|
click to enlarge
|
|
Title
|
HUMAN BCL-2, ISOFORM 2 |
Classification
|
APOPTOSIS |
Compound
|
PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN) |
Source
|
null (BCLX_HUMAN) |
|
Sequence
|
A: |
HAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDDVEENRTE
APEGTESEVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVN
REMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
PSMR
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
110 |
type |
MOD_RES |
sequence |
R
|
description |
Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
2)
|
chain |
A |
residue |
111 |
type |
MOD_RES |
sequence |
D
|
description |
Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
3)
|
chain |
A |
residue |
128 |
type |
MOD_RES |
sequence |
G
|
description |
Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
4)
|
chain |
A |
residue |
137-155 |
type |
prosite |
sequence |
LFRDGVNWGRIVAFFEFGG
|
description |
BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG
|
source |
prosite : PS01080
|
|
5)
|
chain |
A |
residue |
188-199 |
type |
prosite |
sequence |
WIQDNGGWDAFV
|
description |
BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV
|
source |
prosite : PS01258
|
|
6)
|
chain |
A |
residue |
93-107 |
type |
prosite |
sequence |
VHLTLRQAGDDFSRR
|
description |
BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR
|
source |
prosite : PS01259
|
|
7)
|
chain |
A |
residue |
10-30 |
type |
prosite |
sequence |
DNREIVMKYIHYKLSQRGYEW
|
description |
BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW
|
source |
prosite : PS01260
|
|
8)
|
chain |
A |
residue |
34 |
type |
SITE |
sequence |
D
|
description |
Cleavage; by caspase-3
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|