eF-site ID 1gi7-AB PDB Code 1gi7 Chain A, B click to enlarge Title A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE Classification BLOOD CLOTTING, hydrolase Compound UROKINASE-TYPE PLASMINOGEN ACTIVATOR Source Homo sapiens (Human) (UROK_HUMAN) Sequence A:  LKFQCGQKT B:  IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCW VISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVEN LILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI CLPSMYNDPQFGTSCEITGFGKEASTDYLYPEQLKMTVVK LISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW IRSHT Description Functional site 1) chain B residue 185 type sequence D description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 2) chain B residue 185 type sequence D description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 3) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 4) chain B residue 190 type sequence S description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 5) chain B residue 191 type sequence C description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 6) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 7) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 8) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 9) chain B residue 219 type sequence G description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 10) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE 120 B 246 source : AC1 11) chain B residue 67 type sequence Y description BINDING SITE FOR RESIDUE CIT B 1 source : AC2 12) chain B residue 82 type sequence K description BINDING SITE FOR RESIDUE CIT B 1 source : AC2 13) chain B residue 164 type sequence S description BINDING SITE FOR RESIDUE CIT B 1 source : AC2 14) chain B residue 165 type sequence H description BINDING SITE FOR RESIDUE CIT B 1 source : AC2 15) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE CIT B 1 source : AC2 16) chain B residue 36 type sequence R description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 17) chain B residue 82 type sequence K description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 18) chain B residue 110 type sequence S description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 19) chain B residue 165 type sequence H description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 20) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 21) chain B residue 178 type sequence T description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 22) chain B residue 230 type sequence R description BINDING SITE FOR RESIDUE CIT B 2 source : AC3 23) chain B residue 146 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:9151681 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 25) chain B residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 26) chain B residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 27) chain B residue 145 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3 28) chain B residue 53-58 type prosite sequence ISATHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC source prosite : PS00134 29) chain B residue 189-200 type prosite sequence DSCQGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV source prosite : PS00135

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