eF-site ID 1gg5-BD PDB Code 1gg5 Chain B, D click to enlarge Title CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION Classification OXIDOREDUCTASE Compound NAD(P)H DEHYDROGENASE [QUINONE] 1 Source Homo sapiens (Human) (NQO1_HUMAN) Sequence B:  VGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESD LYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHL SPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVF IGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGI HGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADAR IQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKK EVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK D:  VGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESD LYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHL SPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVF IGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGI HGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADAR IQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKK EVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK Description Functional site 1) chain B residue 11 type sequence H description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 2) chain B residue 15 type sequence T description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 3) chain B residue 16 type sequence S description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 4) chain B residue 17 type sequence F description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 5) chain B residue 18 type sequence N description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 6) chain B residue 20 type sequence A description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 7) chain B residue 102 type sequence P description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 8) chain B residue 103 type sequence L description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 9) chain B residue 104 type sequence Q description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 10) chain B residue 105 type sequence W description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 11) chain B residue 106 type sequence F description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 12) chain B residue 147 type sequence T description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 13) chain B residue 148 type sequence T description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 14) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 15) chain B residue 150 type sequence G description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 16) chain B residue 155 type sequence Y description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 17) chain B residue 192 type sequence I description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 18) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 19) chain B residue 204 type sequence L description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 20) chain D residue 66 type sequence Q description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 21) chain D residue 67 type sequence Y description BINDING SITE FOR RESIDUE FAD B 602 source : AC2 22) chain B residue 66 type sequence Q description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 23) chain B residue 67 type sequence Y description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 24) chain B residue 68 type sequence P description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 25) chain D residue 11 type sequence H description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 26) chain D residue 15 type sequence T description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 27) chain D residue 16 type sequence S description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 28) chain D residue 17 type sequence F description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 29) chain D residue 18 type sequence N description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 30) chain D residue 20 type sequence A description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 31) chain D residue 102 type sequence P description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 32) chain D residue 103 type sequence L description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 33) chain D residue 104 type sequence Q description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 34) chain D residue 105 type sequence W description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 35) chain D residue 106 type sequence F description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 36) chain D residue 147 type sequence T description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 37) chain D residue 148 type sequence T description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 38) chain D residue 149 type sequence G description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 39) chain D residue 150 type sequence G description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 40) chain D residue 155 type sequence Y description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 41) chain D residue 192 type sequence I description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 42) chain D residue 200 type sequence R description BINDING SITE FOR RESIDUE FAD D 604 source : AC4 43) chain B residue 105 type sequence W description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 44) chain B residue 106 type sequence F description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 45) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 46) chain B residue 150 type sequence G description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 47) chain B residue 161 type sequence H description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 48) chain D residue 68 type sequence P description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 49) chain D residue 126 type sequence Y description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 50) chain D residue 128 type sequence Y description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 51) chain D residue 178 type sequence F description BINDING SITE FOR RESIDUE E09 D 702 source : AC6 52) chain B residue 68 type sequence P description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 53) chain B residue 126 type sequence Y description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 54) chain B residue 128 type sequence Y description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 55) chain B residue 174 type sequence G description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 56) chain B residue 178 type sequence F description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 57) chain D residue 106 type sequence F description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 58) chain D residue 149 type sequence G description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 59) chain D residue 150 type sequence G description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 60) chain D residue 161 type sequence H description BINDING SITE FOR RESIDUE E09 B 704 source : AC8 61) chain B residue 149 type catalytic sequence G description 3 source MCSA : MCSA2 62) chain B residue 155 type catalytic sequence Y description 3 source MCSA : MCSA2 63) chain B residue 161 type catalytic sequence H description 3 source MCSA : MCSA2 64) chain D residue 149 type catalytic sequence G description 3 source MCSA : MCSA4 65) chain D residue 155 type catalytic sequence Y description 3 source MCSA : MCSA4 66) chain D residue 161 type catalytic sequence H description 3 source MCSA : MCSA4 67) chain B residue 66 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 103 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 147 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 70) chain B residue 155 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 200 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 72) chain D residue 11 type BINDING sequence H description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 73) chain D residue 17 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 74) chain D residue 66 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 75) chain D residue 103 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 76) chain D residue 147 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 77) chain D residue 155 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 78) chain D residue 200 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 79) chain B residue 11 type BINDING sequence H description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 17 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 125 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 82) chain D residue 125 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 83) chain B residue 81 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 84) chain D residue 81 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 85) chain D residue 249 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 86) chain D residue 250 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 87) chain B residue 249 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 88) chain B residue 250 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4

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