eF-site ID 1gbl-AP PDB Code 1gbl Chain A, P click to enlarge Title ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID Classification HYDROLASE/HYDROLASE INHIBITOR Compound ALPHA-LYTIC PROTEASE Source null (1GBL) Sequence A:  ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTV NATARIGGAVVGTFAARVFPGNDRAWVSLTSAQTLLPRVA NGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVT ANYAEGAVRGLTQGNACAGRGDSGGSWITSAGQAQGVMSG GNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG P:  AAPX Description Functional site 1) chain A residue 230 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 2) chain A residue 233 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 3) chain A residue 57 type sequence H description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 4) chain A residue 122 type sequence R description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 5) chain A residue 171 type sequence Y description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 6) chain A residue 191 type sequence G description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 7) chain A residue 193 type sequence G description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 8) chain A residue 194 type sequence D description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 9) chain A residue 195 type sequence S description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 10) chain A residue 214 type sequence S description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 11) chain A residue 215 type sequence G description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 12) chain A residue 216 type sequence G description BINDING SITE FOR CHAIN P OF METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR source : AC2 13) chain A residue 57 type catalytic sequence H description 609 source MCSA : MCSA1 14) chain A residue 102 type catalytic sequence D description 609 source MCSA : MCSA1 15) chain A residue 193 type catalytic sequence G description 609 source MCSA : MCSA1 16) chain A residue 195 type catalytic sequence S description 609 source MCSA : MCSA1 17) chain A residue 214 type catalytic sequence S description 609 source MCSA : MCSA1 18) chain A residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 53-58 type prosite sequence VTAGHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC source prosite : PS00134 22) chain A residue 189-200 type prosite sequence CAGRGDSGGSWI description TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAgrGDSGGSWI source prosite : PS00135

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