eF-site/Summary 1g6v-A

eF-site ID	1g6v-A
PDB Code	1g6v
Chain	A

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Title	Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase
Classification	LYASE/IMMUNE SYSTEM
Compound	CARBONIC ANHYDRASE
Source	ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus;

Sequence	A:	HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPS LKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGP LDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHW NTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVL DSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLL ECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDN WRPAQPLKNRQIKASF

Description

Functional site


1)	chain	A
	residue	94
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 1001
	source	: AC1

2)	chain	A
	residue	96
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 1001
	source	: AC1

3)	chain	A
	residue	119
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 1001
	source	: AC1

4)	chain	A
	residue	199
	type
	sequence	T
	description	BINDING SITE FOR RESIDUE ZN A 1001
	source	: AC1

5)	chain	A
	residue	65
	type	ACT_SITE
	sequence	A
	description	Proton donor/acceptor => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI1

6)	chain	A
	residue	95
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000269\|PubMed:15039588
	source	Swiss-Prot : SWS_FT_FI2

7)	chain	A
	residue	97
	type	BINDING
	sequence	W
	description	BINDING => ECO:0000269\|PubMed:15039588
	source	Swiss-Prot : SWS_FT_FI2

8)	chain	A
	residue	120
	type	BINDING
	sequence	L
	description	BINDING => ECO:0000269\|PubMed:15039588
	source	Swiss-Prot : SWS_FT_FI2

9)	chain	A
	residue	200
	type	BINDING
	sequence	T
	description	BINDING => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	A
	residue	8
	type	SITE
	sequence	G
	description	Fine-tunes the proton-transfer properties of H-64 => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI4

11)	chain	A
	residue	63
	type	SITE
	sequence	G
	description	Fine-tunes the proton-transfer properties of H-64 => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI4

12)	chain	A
	residue	68
	type	SITE
	sequence	V
	description	Fine-tunes the proton-transfer properties of H-64 => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI4

13)	chain	A
	residue	105-121
	type	prosite
	sequence	SEHTVDKKKYAAELHLV
	description	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV
	source	prosite : PS00162

14)	chain	A
	residue	167
	type	MOD_RES
	sequence	I
	description	Phosphoserine => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI6

15)	chain	A
	residue	174
	type	MOD_RES
	sequence	A
	description	Phosphoserine => ECO:0000250\|UniProtKB:P00918
	source	Swiss-Prot : SWS_FT_FI6