eF-site ID 1g6s-A
PDB Code 1g6s
Chain A

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Title STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE AND GLYPHOSATE
Classification TRANSFERASE
Compound EPSP SYNTHASE
Source null (AROA_ECOLI)
Sequence A:  MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTV
LTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGG
PLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR
MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGG
NVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPY
IDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE
GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVL
EKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIAT
AALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE
EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTP
VTILDPKCTAKTFPDYFEQLARISQAA
Description


Functional site
1) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
2) chain A
residue 23
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
3) chain A
residue 27
type
sequence R
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
4) chain A
residue 97
type
sequence T
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
5) chain A
residue 169
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
6) chain A
residue 170
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
7) chain A
residue 171
type
sequence Q
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
8) chain A
residue 197
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
9) chain A
residue 200
type
sequence Y
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
10) chain A
residue 313
type
sequence D
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
11) chain A
residue 336
type
sequence N
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
12) chain A
residue 340
type
sequence K
description BINDING SITE FOR RESIDUE S3P A 601
source : AC1
13) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
14) chain A
residue 94
type
sequence N
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
15) chain A
residue 96
type
sequence G
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
16) chain A
residue 124
type
sequence R
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
17) chain A
residue 171
type
sequence Q
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
18) chain A
residue 313
type
sequence D
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
19) chain A
residue 341
type
sequence E
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
20) chain A
residue 344
type
sequence R
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
21) chain A
residue 385
type
sequence H
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
22) chain A
residue 386
type
sequence R
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
23) chain A
residue 411
type
sequence K
description BINDING SITE FOR RESIDUE GPJ A 701
source : AC2
24) chain A
residue 335
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 801
source : AC3
25) chain A
residue 65
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 802
source : AC4
26) chain A
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 802
source : AC4
27) chain A
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 802
source : AC4
28) chain A
residue 72
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 802
source : AC4
29) chain A
residue 194
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 803
source : AC5
30) chain A
residue 333
type
sequence N
description BINDING SITE FOR RESIDUE FMT A 803
source : AC5
31) chain A
residue 380
type
sequence A
description BINDING SITE FOR RESIDUE FMT A 804
source : AC6
32) chain A
residue 382
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 804
source : AC6
33) chain A
residue 373
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 805
source : AC7
34) chain A
residue 374
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 805
source : AC7
35) chain A
residue 397
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 805
source : AC7
36) chain A
residue 398
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 805
source : AC7
37) chain A
residue 38
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 806
source : AC8
38) chain A
residue 335
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 806
source : AC8
39) chain A
residue 363
type
sequence H
description BINDING SITE FOR RESIDUE FMT A 806
source : AC8
40) chain A
residue 58
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 807
source : AC9
41) chain A
residue 62
type
sequence V
description BINDING SITE FOR RESIDUE FMT A 807
source : AC9
42) chain A
residue 63
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 807
source : AC9
43) chain A
residue 64
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 807
source : AC9
44) chain A
residue 89
type
sequence E
description BINDING SITE FOR RESIDUE FMT A 808
source : BC1
45) chain A
residue 90
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 808
source : BC1
46) chain A
residue 91
type
sequence F
description BINDING SITE FOR RESIDUE FMT A 808
source : BC1
47) chain A
residue 145
type
sequence Q
description BINDING SITE FOR RESIDUE FMT A 809
source : BC2
48) chain A
residue 237
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 809
source : BC2
49) chain A
residue 238
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 809
source : BC2
50) chain A
residue 303
type
sequence A
description BINDING SITE FOR RESIDUE FMT A 810
source : BC3
51) chain A
residue 328
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 810
source : BC3
52) chain A
residue 49
type catalytic
sequence D
description 457
source MCSA : MCSA1
53) chain A
residue 94
type catalytic
sequence N
description 457
source MCSA : MCSA1
54) chain A
residue 313
type catalytic
sequence D
description 457
source MCSA : MCSA1
55) chain A
residue 341
type catalytic
sequence E
description 457
source MCSA : MCSA1
56) chain A
residue 385
type catalytic
sequence H
description 457
source MCSA : MCSA1
57) chain A
residue 386
type catalytic
sequence R
description 457
source MCSA : MCSA1
58) chain A
residue 411
type catalytic
sequence K
description 457
source MCSA : MCSA1
59) chain A
residue 408
type SITE
sequence C
description Modified by bromopyruvate => ECO:0000269|PubMed:11171958
source Swiss-Prot : SWS_FT_FI6
60) chain A
residue 411
type SITE
sequence K
description Modified by bromopyruvate => ECO:0000269|PubMed:11171958
source Swiss-Prot : SWS_FT_FI6
61) chain A
residue 313
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI1
62) chain A
residue 341
type ACT_SITE
sequence E
description Proton donor => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:15736934, ECO:0000305|PubMed:11171958
source Swiss-Prot : SWS_FT_FI2
63) chain A
residue 169
type BINDING
sequence S
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
64) chain A
residue 340
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
65) chain A
residue 22
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
66) chain A
residue 27
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
67) chain A
residue 197
type BINDING
sequence S
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
68) chain A
residue 336
type BINDING
sequence N
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
69) chain A
residue 124
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
70) chain A
residue 344
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
71) chain A
residue 386
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
72) chain A
residue 411
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
73) chain A
residue 90-104
type prosite
sequence LFLGNAGTAMRPLAA
description EPSP_SYNTHASE_1 EPSP synthase signature 1. LFlGNAGTAMRpLaA
source prosite : PS00104
74) chain A
residue 338-356
type prosite
sequence RVKETDRLFAMATELRKVG
description EPSP_SYNTHASE_2 EPSP synthase signature 2. RvKETDRLfAMateLrkVG
source prosite : PS00885

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