eF-site ID 1g6k-AB PDB Code 1g6k Chain A, B click to enlarge Title Crystal structure of glucose dehydrogenase mutant E96A complexed with NAD+ Classification OXIDOREDUCTASE Compound GLUCOSE 1-DEHYDROGENASE Source null (DHG_BACME) Sequence A:  MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRS KEDEANSVLEEIKKVGGEAIAVKGDVTVESDVINLVQSAI KEFGKLDVMINNAGLANPVSSHEMSLSDWNKVIDTNLTGA FLGSREAIKYFVENDIKGTVINMSSVHEKIPWPLFVHYAA SKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKF ADPEQRADVESMIPMGYIGEPEEIAAVAAWLASSEASYVT GITLFADGGMTQYPSFQAGRG B:  MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRS KEDEANSVLEEIKKVGGEAIAVKGDVTVESDVINLVQSAI KEFGKLDVMINNAGLANPVSSHEMSLSDWNKVIDTNLTGA FLGSREAIKYFVENDIKGTVINMSSVHEKIPWPLFVHYAA SKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKF ADPEQRADVESMIPMGYIGEPEEIAAVAAWLASSEASYVT GITLFADGGMTQYPSFQAGRG Description Functional site 1) chain A residue 14 type sequence G description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 2) chain A residue 17 type sequence T description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 3) chain A residue 18 type sequence G description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 4) chain A residue 19 type sequence L description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 5) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 6) chain A residue 64 type sequence G description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 7) chain A residue 65 type sequence D description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 8) chain A residue 66 type sequence V description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 9) chain A residue 92 type sequence N description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 10) chain A residue 93 type sequence A description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 11) chain A residue 94 type sequence G description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 12) chain A residue 115 type sequence T description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 13) chain A residue 143 type sequence M description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 14) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 15) chain A residue 145 type sequence S description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 16) chain A residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 17) chain A residue 162 type sequence K description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 18) chain A residue 188 type sequence P description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 19) chain A residue 189 type sequence G description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 20) chain A residue 191 type sequence I description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 21) chain A residue 193 type sequence T description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 22) chain A residue 195 type sequence I description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 23) chain A residue 196 type sequence N description BINDING SITE FOR RESIDUE NAD A 1262 source : AC1 24) chain B residue 14 type sequence G description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 25) chain B residue 17 type sequence T description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 26) chain B residue 18 type sequence G description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 27) chain B residue 19 type sequence L description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 28) chain B residue 64 type sequence G description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 29) chain B residue 65 type sequence D description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 30) chain B residue 66 type sequence V description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 31) chain B residue 92 type sequence N description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 32) chain B residue 93 type sequence A description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 33) chain B residue 94 type sequence G description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 34) chain B residue 115 type sequence T description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 35) chain B residue 143 type sequence M description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 36) chain B residue 144 type sequence S description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 37) chain B residue 145 type sequence S description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 38) chain B residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 39) chain B residue 162 type sequence K description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 40) chain B residue 188 type sequence P description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 41) chain B residue 189 type sequence G description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 42) chain B residue 191 type sequence I description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 43) chain B residue 193 type sequence T description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 44) chain B residue 195 type sequence I description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 45) chain B residue 196 type sequence N description BINDING SITE FOR RESIDUE NAD B 2262 source : AC2 46) chain A residue 158 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 47) chain B residue 158 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 48) chain A residue 145-173 type prosite sequence SVHEKIPWPLFVHYAASKGGMKLMTETLA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvhekipwplFvhYAASKGGMkLMTeTLA source prosite : PS00061 49) chain B residue 11 type BINDING sequence V description BINDING => ECO:0000269|PubMed:11173533 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 11 type BINDING sequence V description BINDING => ECO:0000269|PubMed:11173533 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 145 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 52) chain A residue 145 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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