|
eF-site ID
|
1g65-N |
PDB Code
|
1g65 |
Chain
|
N |
|
click to enlarge
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Title
|
Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors |
Classification
|
HYDROLASE/HYDROLASE inhibitor |
Compound
|
Proteasome component Y7 |
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
Sequence
|
N: |
TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
N |
residue |
19 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE MG N 201
|
source |
: BC1
|
|
2)
|
chain |
N |
residue |
163 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE MG N 201
|
source |
: BC1
|
|
3)
|
chain |
N |
residue |
166 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG N 201
|
source |
: BC1
|
|
4)
|
chain |
N |
residue |
169 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE MG N 201
|
source |
: BC1
|
|
5)
|
chain |
N |
residue |
1 |
type |
ACT_SITE |
sequence |
T
|
description |
Nucleophile => ECO:0000269|PubMed:9087403
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|