eF-site ID 1g65-L PDB Code 1g65 Chain L click to enlarge Title Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors Classification HYDROLASE/HYDROLASE inhibitor Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence L:  QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD GLEILIVTKDGVRKEFYELKRD Description Functional site 1) chain L residue 75 type sequence S description BINDING SITE FOR RESIDUE MG D 301 source : AC1 2) chain L residue 78 type sequence S description BINDING SITE FOR RESIDUE MG D 301 source : AC1 3) chain L residue 163 type sequence T description BINDING SITE FOR RESIDUE MG L 201 source : AC9 4) chain L residue 166 type sequence H description BINDING SITE FOR RESIDUE MG L 201 source : AC9 5) chain L residue 169 type sequence V description BINDING SITE FOR RESIDUE MG L 201 source : AC9 6) chain L residue 114 type sequence D description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 7) chain L residue 115 type sequence P description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 8) chain L residue 116 type sequence V description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 9) chain L residue 4-51 type prosite sequence LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM SANGFAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD source prosite : PS00854

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