eF-site ID 1g65-K PDB Code 1g65 Chain K click to enlarge Title Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors Classification HYDROLASE/HYDROLASE inhibitor Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence K:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain K residue 19 type sequence R description BINDING SITE FOR RESIDUE MG K 301 source : AC8 2) chain K residue 163 type sequence A description BINDING SITE FOR RESIDUE MG K 301 source : AC8 3) chain K residue 166 type sequence D description BINDING SITE FOR RESIDUE MG K 301 source : AC8 4) chain K residue 167 type sequence A description BINDING SITE FOR RESIDUE MG K 301 source : AC8 5) chain K residue 169 type sequence S description BINDING SITE FOR RESIDUE MG K 301 source : AC8 6) chain K residue 1 type sequence T description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 7) chain K residue 19 type sequence R description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 8) chain K residue 20 type sequence A description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 9) chain K residue 21 type sequence T description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 10) chain K residue 47 type sequence G description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 11) chain K residue 49 type sequence A description BINDING SITE FOR CHAIN 3 OF EPOXOMICIN (PEPTIDE INHIBITOR) source : BC2 12) chain K residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD source prosite : PS00854 13) chain K residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2

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