eF-site ID 1g65-I PDB Code 1g65 Chain I click to enlarge Title Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors Classification HYDROLASE/HYDROLASE inhibitor Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence I:  SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFE KIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERA IEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFI AGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPE DLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK MRQD Description Functional site 1) chain I residue 128 type sequence G description BINDING SITE FOR RESIDUE MG I 201 source : AC6 2) chain I residue 131 type sequence S description BINDING SITE FOR RESIDUE MG I 201 source : AC6 3) chain I residue 163 type sequence A description BINDING SITE FOR RESIDUE MG I 202 source : AC7 4) chain I residue 166 type sequence D description BINDING SITE FOR RESIDUE MG I 202 source : AC7 5) chain I residue 169 type sequence S description BINDING SITE FOR RESIDUE MG I 202 source : AC7 6) chain I residue 4-51 type prosite sequence VAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLG ITGLATD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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