eF-site ID 1g65-H PDB Code 1g65 Chain H click to enlarge Title Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors Classification HYDROLASE/HYDROLASE inhibitor Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain H residue 19 type sequence R description BINDING SITE FOR RESIDUE MG H 301 source : AC5 2) chain H residue 163 type sequence I description BINDING SITE FOR RESIDUE MG H 301 source : AC5 3) chain H residue 166 type sequence D description BINDING SITE FOR RESIDUE MG H 301 source : AC5 4) chain H residue 169 type sequence S description BINDING SITE FOR RESIDUE MG H 301 source : AC5 5) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 6) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 7) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 8) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 9) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 10) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 11) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 12) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1 13) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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