eF-site ID 1g65-G PDB Code 1g65 Chain G click to enlarge Title Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors Classification HYDROLASE/HYDROLASE inhibitor Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence G:  AGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKD CTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPD ARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYT QRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKAT ATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITH MIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIA EQD Description Functional site 1) chain G residue 127 type sequence A description BINDING SITE FOR RESIDUE MG F 302 source : AC3 2) chain G residue 13 type sequence T description BINDING SITE FOR RESIDUE MG G 301 source : AC4 3) chain G residue 123 type sequence Y description BINDING SITE FOR RESIDUE MG G 301 source : AC4 4) chain G residue 126 type sequence R description BINDING SITE FOR RESIDUE MG G 301 source : AC4 5) chain G residue 127 type sequence A description BINDING SITE FOR RESIDUE MG G 301 source : AC4 6) chain G residue 129 type sequence M description BINDING SITE FOR RESIDUE MG G 301 source : AC4 7) chain G residue 8-30 type prosite sequence YDRHITIFSPEGRLYQVEYAFKA description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA source prosite : PS00388

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