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eF-site ID
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1g65-E |
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PDB Code
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1g65 |
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Chain
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E |
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click to enlarge
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Title
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Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors |
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Classification
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HYDROLASE/HYDROLASE inhibitor |
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Compound
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Proteasome component Y7 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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E: |
FRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSN
THAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDA
RVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQ
SYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAI
GARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSL
RDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI
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Description
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Functional site
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1)
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chain |
E |
| residue |
8-30 |
| type |
prosite |
| sequence |
YDGDTVTFSPTGRLFQVEYALEA
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| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdsrtTiFSPeGRlyQVEYAleS
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| source |
prosite : PS00388
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