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eF-site ID
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1g65-B |
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PDB Code
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1g65 |
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Chain
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B |
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click to enlarge
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Title
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Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors |
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Classification
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HYDROLASE/HYDROLASE inhibitor |
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Compound
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Proteasome component Y7 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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B: |
GSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMAS
DGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLT
ADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQG
YTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWK
AISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTT
DSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVK
TGIT
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Description
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Functional site
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1)
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chain |
B |
| residue |
199 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
B |
| residue |
225 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
|
| source |
Swiss-Prot : SWS_FT_FI1
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3)
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chain |
B |
| residue |
8-30 |
| type |
prosite |
| sequence |
YDSRTTIFSPEGRLYQVEYALES
|
| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrhiTiFSPeGRlyQVEYAfkA
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| source |
prosite : PS00388
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4)
|
chain |
B |
| residue |
38-84 |
| type |
prosite |
| sequence |
IGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAV
AVAGLTAD
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| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD
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| source |
prosite : PS00854
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