|
|
eF-site ID
|
1g65-2 |
|
PDB Code
|
1g65 |
|
Chain
|
2 |
|
click to enlarge
|
|
|
Title
|
Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors |
|
Classification
|
HYDROLASE/HYDROLASE inhibitor |
|
Compound
|
Proteasome component Y7 |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
2: |
TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
2 |
| residue |
1 |
| type |
ACT_SITE |
| sequence |
T
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
2 |
| residue |
4-51 |
| type |
prosite |
| sequence |
MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC
CRSGSAAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD
|
| source |
prosite : PS00854
|
|
|
|