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eF-site ID
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1g65-1 |
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PDB Code
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1g65 |
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Chain
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1 |
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click to enlarge
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Title
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Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors |
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Classification
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HYDROLASE/HYDROLASE inhibitor |
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Compound
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Proteasome component Y7 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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1: |
TQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVE
RLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPL
ADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQ
SNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVD
RESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAII
DKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
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Description
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Functional site
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1)
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chain |
1 |
| residue |
26 |
| type |
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| sequence |
L
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| description |
BINDING SITE FOR RESIDUE MG N 201
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| source |
: BC1
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2)
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chain |
1 |
| residue |
4-51 |
| type |
prosite |
| sequence |
ISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVV
GISGDISD
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| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
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| source |
prosite : PS00854
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