|
|
eF-site ID
|
1fyt-ABCDE |
|
PDB Code
|
1fyt |
|
Chain
|
A, B, C, D, E |
|
click to enlarge
|
|
|
Title
|
CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1 |
|
Classification
|
IMMUNE SYSTEM |
|
Compound
|
HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN |
|
Source
|
(TCB_HUMAN) |
|
|
Sequence
|
A: |
KEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKET
VWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTP
ITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTW
LRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVY
DCRVEHWGLDEPLLKHWEFD
|
| B: |
TRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDS
DVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHN
YGVGESFTVQRRVEPKVTVYPSLLVCSVSGFYPGSIEVRW
FRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVY
TCQVEHPSVTSPLTVEWRA
|
| C: |
PKYVKQNTLKLAT
|
| D: |
QSVTQLGSHVSVSEGALVLLRCNYSSSVPPYLFWYVQYPN
QGLQLLLKYTSAATLVKGINGFEAEFKKSETSFHLTKPSA
HMSDAAEYFCAVSESPFGNEKLTFGTGTRLTIIPNIQNPD
PAVYQLRSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTV
LDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTF
|
| E: |
KVTQSSRYLVKRTGEKVFLECVQDMDHENMFWYRQDPGLG
LRLIYFSYDVKMKEKGDIPEGYSVSREKKERFSLILESAS
TNQTSMYLCASSSTGLPYGYTFGSGTRLTVVEDLNKVFPP
EVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNG
KEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQN
PRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
55 |
| type |
SITE |
| sequence |
E
|
| description |
Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
2)
|
chain |
A |
| residue |
62 |
| type |
SITE |
| sequence |
N
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
3)
|
chain |
A |
| residue |
69 |
| type |
SITE |
| sequence |
N
|
| description |
Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
4)
|
chain |
A |
| residue |
76 |
| type |
SITE |
| sequence |
R
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
5)
|
chain |
A |
| residue |
78 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
6)
|
chain |
A |
| residue |
118 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
7)
|
chain |
B |
| residue |
171-177 |
| type |
prosite |
| sequence |
YTCQVEH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
|
| source |
prosite : PS00290
|
|
|
8)
|
chain |
A |
| residue |
161-167 |
| type |
prosite |
| sequence |
YDCRVEH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
|
| source |
prosite : PS00290
|
|
|
9)
|
chain |
D |
| residue |
149 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
D |
| residue |
183 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
B |
| residue |
81 |
| type |
CARBOHYD |
| sequence |
H
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
B |
| residue |
82 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
D |
| residue |
194 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
14)
|
chain |
A |
| residue |
52 |
| type |
CARBOHYD |
| sequence |
A
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
15)
|
chain |
E |
| residue |
50 |
| type |
CARBOHYD |
| sequence |
Y
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
16)
|
chain |
A |
| residue |
53 |
| type |
SITE |
| sequence |
S
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|