eF-site ID 1fv9-A
PDB Code 1fv9
Chain A

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Title Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole
Classification BLOOD CLOTTING
Compound UROKINASE
Source Homo sapiens (Human) (UROK_HUMAN)
Sequence A:  IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCW
VISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVEN
LILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI
ALPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVK
LISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW
IRSHT
Description (1)  UROKINASE (E.C.3.4.21.73)


Functional site

1) chain A
residue 45
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 245
source : AC1

2) chain A
residue 194
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 245
source : AC1

3) chain A
residue 195
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 245
source : AC1

4) chain A
residue 197
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 245
source : AC1

5) chain A
residue 191
type
sequence D
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

6) chain A
residue 192
type
sequence S
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

7) chain A
residue 193
type
sequence C
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

8) chain A
residue 194
type
sequence Q
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

9) chain A
residue 215
type
sequence V
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

10) chain A
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

11) chain A
residue 220
type
sequence G
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

12) chain A
residue 228
type
sequence G
description BINDING SITE FOR RESIDUE 172 A 246
source : AC2

13) chain A
residue 41-46
type prosite
sequence ISATHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
source prosite : PS00134

14) chain A
residue 191-202
type prosite
sequence DSCQGDSGGPLV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
source prosite : PS00135

15) chain A
residue 45
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 96
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 197
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 144
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:9151681
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 143
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine
source Swiss-Prot : SWS_FT_FI3


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