eF-site ID 1fv1-D PDB Code 1fv1 Chain D click to enlarge Title STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES Classification IMMUNE SYSTEM Compound MAJOR HISTOCOMPATIBILITY COMPLEX ALPHA CHAIN Source Homo sapiens (Human) (MBP_HUMAN) Sequence D:  EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEFD Description (1)  MAJOR HISTOCOMPATIBILITY COMPLEX ALPHA CHAIN/MAJOR HISTOCOMPATIBILITY COMPLEX BETA CHAIN/MYELIN BASIC PROTEIN Functional site 1) chain D residue 123 type sequence R description BINDING SITE FOR RESIDUE SO4 D 182 source : AC1 2) chain D residue 124 type sequence N description BINDING SITE FOR RESIDUE SO4 D 182 source : AC1 3) chain D residue 126 type sequence K description BINDING SITE FOR RESIDUE SO4 D 182 source : AC1 4) chain D residue 110 type sequence D description BINDING SITE FOR RESIDUE GOL D 183 source : AC4 5) chain D residue 111 type sequence K description BINDING SITE FOR RESIDUE GOL D 183 source : AC4 6) chain D residue 140 type sequence R description BINDING SITE FOR RESIDUE GOL D 183 source : AC4 7) chain D residue 67 type sequence K description BINDING SITE FOR RESIDUE GOL B 192 source : AC5 8) chain D residue 71 type sequence E description BINDING SITE FOR RESIDUE GOL B 192 source : AC5 9) chain D residue 49 type MOD_RES sequence G description Phosphothreonine => ECO:0000250|UniProtKB:P02688 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 52 type MOD_RES sequence A description Phosphothreonine => ECO:0000250|UniProtKB:P02688 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 12) chain D residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 13) chain D residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 14) chain D residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 15) chain D residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9

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