|
|
eF-site ID
|
1fv1-A |
|
PDB Code
|
1fv1 |
|
Chain
|
A |
|
click to enlarge
|
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Title
|
STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES |
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Classification
|
IMMUNE SYSTEM |
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Compound
|
MAJOR HISTOCOMPATIBILITY COMPLEX ALPHA CHAIN |
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Source
|
Homo sapiens (Human) (MBP_HUMAN) |
|
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Sequence
|
A: |
EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWEFD
|
|
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Description
|
(1) |
MAJOR HISTOCOMPATIBILITY COMPLEX ALPHA CHAIN/MAJOR HISTOCOMPATIBILITY COMPLEX BETA CHAIN/MYELIN BASIC PROTEIN
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
123 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE SO4 A 182
|
| source |
: AC2
|
|
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2)
|
chain |
A |
| residue |
124 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE SO4 A 182
|
| source |
: AC2
|
|
|
3)
|
chain |
A |
| residue |
126 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE SO4 A 182
|
| source |
: AC2
|
|
|
4)
|
chain |
A |
| residue |
62 |
| type |
SITE |
| sequence |
N
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
5)
|
chain |
A |
| residue |
69 |
| type |
SITE |
| sequence |
N
|
| description |
Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
6)
|
chain |
A |
| residue |
76 |
| type |
SITE |
| sequence |
R
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
7)
|
chain |
A |
| residue |
78 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
8)
|
chain |
A |
| residue |
118 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
9)
|
chain |
A |
| residue |
161-167 |
| type |
prosite |
| sequence |
YDCRVEH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
|
| source |
prosite : PS00290
|
|
|
|