eF-site ID 1fuq-A PDB Code 1fuq Chain A click to enlarge Title FUMARASE WITH BOUND 3-TRIMETHYLSILYLSUCCINIC ACID Classification LYASE Compound FUMARASE C Source null (FUMC_ECOLI) Sequence A:  VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTS LIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAG QHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRG MERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQ LKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISG WVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYA RRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKG LAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPG KVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRP MVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLN ESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALG YLSEAEFDSWVRPEQM Description Functional site 1) chain A residue 126 type sequence R description BINDING SITE FOR RESIDUE SIF A 1000 source : AC1 2) chain A residue 129 type sequence H description BINDING SITE FOR RESIDUE SIF A 1000 source : AC1 3) chain A residue 130 type sequence P description BINDING SITE FOR RESIDUE SIF A 1000 source : AC1 4) chain A residue 131 type sequence N description BINDING SITE FOR RESIDUE SIF A 1000 source : AC1 5) chain A residue 132 type sequence D description BINDING SITE FOR RESIDUE SIF A 1000 source : AC1 6) chain A residue 100 type sequence T description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 7) chain A residue 139 type sequence S description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 8) chain A residue 140 type sequence S description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 9) chain A residue 141 type sequence N description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 10) chain A residue 324 type sequence K description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 11) chain A residue 326 type sequence N description BINDING SITE FOR RESIDUE CIT A 1001 source : AC2 12) chain A residue 187 type sequence T description BINDING SITE FOR RESIDUE CIT B 1002 source : AC4 13) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE CIT B 1002 source : AC4 14) chain A residue 188 type catalytic sequence H description 569 source MCSA : MCSA1 15) chain A residue 318 type catalytic sequence S description 569 source MCSA : MCSA1 16) chain A residue 324 type catalytic sequence K description 569 source MCSA : MCSA1 17) chain A residue 331 type catalytic sequence E description 569 source MCSA : MCSA1 18) chain A residue 129 type BINDING sequence H description in site B => ECO:0000269|PubMed:12021453, ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1FUR, ECO:0007744|PDB:1KQ7 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 188 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:9098893 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 318 type ACT_SITE sequence S description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00743 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 98 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:12021453, ECO:0000305|PubMed:8909293, ECO:0000305|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1KQ7, ECO:0007744|PDB:2FUS source Swiss-Prot : SWS_FT_FI3 22) chain A residue 126 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1FUR source Swiss-Prot : SWS_FT_FI4 23) chain A residue 317-326 type prosite sequence GSSIMPGKVN description FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN source prosite : PS00163 24) chain A residue 139 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:12021453, ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1KQ7, ECO:0007744|PDB:2FUS source Swiss-Prot : SWS_FT_FI6 25) chain A residue 187 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00743 source Swiss-Prot : SWS_FT_FI7 26) chain A residue 319 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00743 source Swiss-Prot : SWS_FT_FI7 27) chain A residue 324 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00743 source Swiss-Prot : SWS_FT_FI7 28) chain A residue 331 type SITE sequence E description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:8909293 source Swiss-Prot : SWS_FT_FI8

Display surface Download Links