eF-site ID 1fss-AB PDB Code 1fss Chain A, B click to enlarge Title ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II Classification COMPLEX (SERINE ESTERASE/TOXIN) Compound ACETYLCHOLINESTERASE Source ORGANISM_COMMON: Pacific electric ray; ORGANISM_SCIENTIFIC: Torpedo californica; Sequence A:  SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNM RFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEM WNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSG SSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQE APGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGG ASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRR RAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLP FDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGV NKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHA NDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICP LMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYE IEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPN EPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVF WNQFLPKLLNAT B:  TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCG CPPGDDNLEVKCCTSPDKCNY Description (1)  ACETYLCHOLINESTERASE, FASCICULIN II Functional site 1) chain A residue 416 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899 source Swiss-Prot : SWS_FT_FI4 2) chain A residue 457 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299 source Swiss-Prot : SWS_FT_FI5 3) chain A residue 533 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299 source Swiss-Prot : SWS_FT_FI5 4) chain B residue 33 type SITE sequence M description Blocks the entrance of the active site gorge of hAChE => ECO:0000303|PubMed:23679855 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 59 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 187-202 type prosite sequence FGGDPKTVTIFGESAG description CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpktVtIfGeSAG source prosite : PS00122 7) chain A residue 92-102 type prosite sequence EDCLYLNIWVP description CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP source prosite : PS00941 8) chain B residue 38-56 type prosite sequence GCGCPPGDDNLEVKCCTSP description SNAKE_TOXIN Snake toxins signature. GCg..CPpgddnlevk.CCtsP source prosite : PS00272 9) chain A residue 440 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI2 10) chain A residue 327 type ACT_SITE sequence E description Charge relay system source Swiss-Prot : SWS_FT_FI2

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