eF-site ID 1fqk-ABCD PDB Code 1fqk Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)] Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(t) subunit alpha-1,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(t) subunit alpha-1 Source Bos taurus (Bovine) (RGS9_BOVIN) Sequence A:  RTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIA IIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMA DTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDS AGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSF KDLNFRMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYD LVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKK DLFEEKIKKSPLTICYPEYAGSNTYEEAGNYIKVQFLELN MRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLK B:  LVDIPTKMRVERWAFNFSELIRDPKGRQSFQHFLRKEFSG ENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWI NIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYAR YLKSPIYKEMLAKAIE C:  TVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAI IYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMAD TIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSA GYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFK DLNFRMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDL VLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKD LFEEKIKKSPLTICYPEYAGSNTYEEAGNYIKVQFLELNM RRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLK D:  FWDLNAKLVDIPTKMRVERWAFNFSELIRDPKGRQSFQHF LRKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLA PGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLM KKDSYARYLKSPIYKEMLAKAIE Description Functional site 1) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE MG A 352 source : AC1 2) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE MG A 352 source : AC1 3) chain A residue 37 type sequence A description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 4) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 5) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 6) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 7) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 8) chain A residue 175 type sequence V description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 9) chain A residue 176 type sequence K description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 10) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 11) chain A residue 199 type sequence G description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 12) chain A residue 200 type sequence Q description BINDING SITE FOR RESIDUE ALF A 362 source : AC2 13) chain C residue 43 type sequence S description BINDING SITE FOR RESIDUE MG C 352 source : AC3 14) chain C residue 177 type sequence T description BINDING SITE FOR RESIDUE MG C 352 source : AC3 15) chain C residue 38 type sequence G description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 16) chain C residue 39 type sequence E description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 17) chain C residue 42 type sequence K description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 18) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 19) chain C residue 175 type sequence V description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 20) chain C residue 176 type sequence K description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 21) chain C residue 177 type sequence T description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 22) chain C residue 199 type sequence G description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 23) chain C residue 200 type sequence Q description BINDING SITE FOR RESIDUE ALF C 363 source : AC4 24) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 25) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 26) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 27) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 28) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 29) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 30) chain A residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 31) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 32) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 33) chain A residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 34) chain A residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 35) chain A residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 36) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 37) chain A residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 38) chain A residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 39) chain A residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 40) chain A residue 269 type sequence L description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 41) chain A residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 42) chain A residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 43) chain A residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP A 360 source : AC5 44) chain C residue 38 type sequence G description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 45) chain C residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 46) chain C residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 47) chain C residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 48) chain C residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 49) chain C residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 50) chain C residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 51) chain C residue 146 type sequence D description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 52) chain C residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 53) chain C residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 54) chain C residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 55) chain C residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 56) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 57) chain C residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 58) chain C residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 59) chain C residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 60) chain C residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 61) chain C residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 62) chain C residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP C 361 source : AC6 63) chain A residue 36 type BINDING sequence G description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 171 type BINDING sequence L description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 66) chain C residue 36 type BINDING sequence G description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 67) chain C residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 68) chain C residue 171 type BINDING sequence L description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 69) chain A residue 43 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 70) chain A residue 177 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 71) chain C residue 43 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 72) chain C residue 177 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 73) chain A residue 199 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 74) chain A residue 322 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 75) chain C residue 199 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 76) chain C residue 322 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 77) chain A residue 142 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI4 78) chain C residue 142 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI4 79) chain A residue 265 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI5 80) chain C residue 265 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI5

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