eF-site ID 1fo4-B PDB Code 1fo4 Chain B click to enlarge Title CRYSTAL STRUCTURE OF XANTHINE DEHYDROGENASE ISOLATED FROM BOVINE MILK Classification OXIDOREDUCTASE Compound XANTHINE DEHYDROGENASE Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence B:  ADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLG CGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHH VAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVM SMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRT FAKSPSLFNPEEFMPLDPTQEPIFPPELLRLKDVPPKQLR FEGERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEM KFKNQLFPMIICPAWIPELNAVEHGPEGISFGAACALSSV EKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASL GGNIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHT FFPSYRKTLLGPEEILLSIEIPYSREDEFFSAFKQASRRE DDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALK TTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFR RTLTLSFFFKFYLTVLKKLGKLDPTYTSATLLFQKHPPAN IQLFQEVPNGQSKEDTVGRPLPHLAAAMQASGEAVYCDDI PRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLS ADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPE HAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEK GDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGE EGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGG GFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLIT GGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHS IMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGG PQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFN QRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKR GLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGT EMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSP TAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDW VMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYG VACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVE GAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIP TEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKD AIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTL CVTGAPGNCKPWSLRV Description Functional site 1) chain B residue 867 type sequence A description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 2) chain B residue 870 type sequence S description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 3) chain B residue 871 type sequence R description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 4) chain B residue 872 type sequence D description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 5) chain B residue 874 type sequence S description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 6) chain B residue 907 type sequence S description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 7) chain B residue 908 type sequence N description BINDING SITE FOR RESIDUE CA B 4019 source : AC2 8) chain B residue 112 type sequence Q description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 9) chain B residue 113 type sequence C description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 10) chain B residue 114 type sequence G description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 11) chain B residue 116 type sequence C description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 12) chain B residue 148 type sequence C description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 13) chain B residue 149 type sequence R description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 14) chain B residue 150 type sequence C description BINDING SITE FOR RESIDUE FES B 4001 source : AC9 15) chain B residue 42 type sequence G description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 16) chain B residue 43 type sequence C description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 17) chain B residue 44 type sequence G description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 18) chain B residue 46 type sequence G description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 19) chain B residue 47 type sequence G description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 20) chain B residue 48 type sequence C description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 21) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 22) chain B residue 51 type sequence C description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 23) chain B residue 71 type sequence N description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 24) chain B residue 73 type sequence C description BINDING SITE FOR RESIDUE FES B 4002 source : BC1 25) chain B residue 112 type sequence Q description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 26) chain B residue 150 type sequence C description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 27) chain B residue 796 type sequence G description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 28) chain B residue 797 type sequence G description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 29) chain B residue 798 type sequence F description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 30) chain B residue 912 type sequence R description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 31) chain B residue 1038 type sequence M description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 32) chain B residue 1039 type sequence G description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 33) chain B residue 1040 type sequence Q description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 34) chain B residue 1078 type sequence A description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 35) chain B residue 1079 type sequence A description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 36) chain B residue 1080 type sequence S description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 37) chain B residue 1081 type sequence V description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 38) chain B residue 1082 type sequence S description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 39) chain B residue 1194 type sequence Q description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 40) chain B residue 1261 type sequence E description BINDING SITE FOR RESIDUE MTE B 4003 source : BC2 41) chain B residue 767 type sequence Q description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 42) chain B residue 798 type sequence F description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 43) chain B residue 799 type sequence G description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 44) chain B residue 802 type sequence E description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 45) chain B residue 911 type sequence F description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 46) chain B residue 912 type sequence R description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 47) chain B residue 1078 type sequence A description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 48) chain B residue 1079 type sequence A description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 49) chain B residue 1261 type sequence E description BINDING SITE FOR RESIDUE MOS B 4004 source : BC3 50) chain B residue 802 type sequence E description BINDING SITE FOR RESIDUE SAL B 4005 source : BC4 51) chain B residue 880 type sequence R description BINDING SITE FOR RESIDUE SAL B 4005 source : BC4 52) chain B residue 914 type sequence F description BINDING SITE FOR RESIDUE SAL B 4005 source : BC4 53) chain B residue 1009 type sequence F description BINDING SITE FOR RESIDUE SAL B 4005 source : BC4 54) chain B residue 1010 type sequence T description BINDING SITE FOR RESIDUE SAL B 4005 source : BC4 55) chain B residue 45 type sequence E description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 56) chain B residue 46 type sequence G description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 57) chain B residue 47 type sequence G description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 58) chain B residue 74 type sequence L description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 59) chain B residue 256 type sequence K description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 60) chain B residue 257 type sequence L description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 61) chain B residue 258 type sequence V description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 62) chain B residue 259 type sequence V description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 63) chain B residue 260 type sequence G description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 64) chain B residue 261 type sequence N description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 65) chain B residue 262 type sequence T description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 66) chain B residue 263 type sequence E description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 67) chain B residue 264 type sequence I description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 68) chain B residue 301 type sequence A description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 69) chain B residue 337 type sequence F description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 70) chain B residue 338 type sequence A description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 71) chain B residue 342 type sequence V description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 72) chain B residue 346 type sequence A description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 73) chain B residue 347 type sequence S description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 74) chain B residue 350 type sequence G description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 75) chain B residue 351 type sequence N description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 76) chain B residue 353 type sequence I description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 77) chain B residue 359 type sequence S description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 78) chain B residue 360 type sequence D description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 79) chain B residue 403 type sequence I description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 80) chain B residue 404 type sequence L description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 81) chain B residue 422 type sequence K description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 82) chain B residue 429 type sequence D description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 83) chain B residue 430 type sequence D description BINDING SITE FOR RESIDUE FAD B 4006 source : BC5 84) chain B residue 839 type sequence R description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 85) chain B residue 840 type sequence H description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 86) chain B residue 877 type sequence I description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 87) chain B residue 909 type sequence T description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 88) chain B residue 910 type sequence A description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 89) chain B residue 911 type sequence F description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 90) chain B residue 913 type sequence G description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 91) chain B residue 914 type sequence F description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 92) chain B residue 915 type sequence G description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 93) chain B residue 918 type sequence Q description BINDING SITE FOR RESIDUE GOL B 4007 source : BC8 94) chain B residue 561 type sequence Q description BINDING SITE FOR RESIDUE GOL B 4008 source : BC9 95) chain B residue 574 type sequence G description BINDING SITE FOR RESIDUE GOL B 4008 source : BC9 96) chain B residue 1184 type sequence S description BINDING SITE FOR RESIDUE GOL B 4008 source : BC9 97) chain B residue 1185 type sequence S description BINDING SITE FOR RESIDUE GOL B 4008 source : BC9 98) chain B residue 802 type catalytic sequence E description 139 source MCSA : MCSA2 99) chain B residue 880 type catalytic sequence R description 139 source MCSA : MCSA2 100) chain B residue 1261 type catalytic sequence E description 139 source MCSA : MCSA2 101) chain B residue 1261 type ACT_SITE sequence E description Proton acceptor => ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI1 102) chain B residue 43 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 103) chain B residue 48 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 104) chain B residue 51 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 105) chain B residue 73 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 106) chain B residue 113 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 116 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 148 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 109) chain B residue 150 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 110) chain B residue 767 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 111) chain B residue 798 type BINDING sequence F description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 112) chain B residue 912 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 113) chain B residue 1079 type BINDING sequence A description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252 source Swiss-Prot : SWS_FT_FI2 114) chain B residue 360 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 115) chain B residue 404 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 116) chain B residue 422 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 117) chain B residue 257 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 118) chain B residue 337 type BINDING sequence F description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 119) chain B residue 347 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401 source Swiss-Prot : SWS_FT_FI3 120) chain B residue 802 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI4 121) chain B residue 880 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI4 122) chain B residue 914 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI4 123) chain B residue 1010 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI4

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