eF-site ID 1fmc-B PDB Code 1fmc Chain B click to enlarge Title 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEX WITH NADH AND 7-OXO GLYCOCHENODEOXYCHOLIC ACID Classification OXIDOREDUCTASE Compound 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE Source Escherichia coli (strain K12) (HDHA_ECOLI) Sequence B:  MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVV SDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALAD FAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVF SFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYA SSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSV ITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVS GQILTVSGGGVQELN Description Functional site 1) chain B residue 98 type sequence G description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 2) chain B residue 99 type sequence G description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 3) chain B residue 146 type sequence S description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 4) chain B residue 148 type sequence A description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 5) chain B residue 151 type sequence N description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 6) chain B residue 156 type sequence M description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 7) chain B residue 159 type sequence Y description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 8) chain B residue 190 type sequence G description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 9) chain B residue 197 type sequence L description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 10) chain B residue 252 type sequence Q description BINDING SITE FOR RESIDUE CHO B 301 source : AC3 11) chain B residue 18 type sequence G description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 12) chain B residue 21 type sequence A description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 13) chain B residue 22 type sequence G description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 14) chain B residue 23 type sequence I description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 15) chain B residue 42 type sequence D description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 16) chain B residue 43 type sequence I description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 17) chain B residue 67 type sequence C description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 18) chain B residue 68 type sequence D description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 19) chain B residue 69 type sequence I description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 20) chain B residue 95 type sequence N description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 21) chain B residue 97 type sequence G description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 22) chain B residue 144 type sequence I description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 23) chain B residue 145 type sequence T description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 24) chain B residue 159 type sequence Y description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 25) chain B residue 163 type sequence K description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 26) chain B residue 189 type sequence P description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 27) chain B residue 190 type sequence G description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 28) chain B residue 192 type sequence I description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 29) chain B residue 194 type sequence T description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 30) chain B residue 196 type sequence A description BINDING SITE FOR RESIDUE NAI B 302 source : AC4 31) chain B residue 159 type ACT_SITE sequence Y description Proton acceptor => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 159 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI2 33) chain B residue 23 type BINDING sequence I description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI2 34) chain B residue 99 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI2 35) chain B residue 146 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI2 36) chain B residue 151 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI2 37) chain B residue 192 type BINDING sequence I description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI3 38) chain B residue 42 type BINDING sequence D description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI3 39) chain B residue 68 type BINDING sequence D description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI3 40) chain B residue 95 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI3 41) chain B residue 163 type BINDING sequence K description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC source Swiss-Prot : SWS_FT_FI3 42) chain B residue 146 type SITE sequence S description Transition state stabilizer => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 163 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 source Swiss-Prot : SWS_FT_FI5

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