eF-site ID 1fmc-B
PDB Code 1fmc
Chain B

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Title 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEX WITH NADH AND 7-OXO GLYCOCHENODEOXYCHOLIC ACID
Classification OXIDOREDUCTASE
Compound 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE
Source Escherichia coli (strain K12) (HDHA_ECOLI)
Sequence B:  MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVV
SDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALAD
FAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVF
SFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYA
SSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSV
ITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVS
GQILTVSGGGVQELN
Description


Functional site

1) chain B
residue 98
type
sequence G
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

2) chain B
residue 99
type
sequence G
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

3) chain B
residue 146
type
sequence S
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

4) chain B
residue 148
type
sequence A
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

5) chain B
residue 151
type
sequence N
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

6) chain B
residue 156
type
sequence M
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

7) chain B
residue 159
type
sequence Y
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

8) chain B
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

9) chain B
residue 197
type
sequence L
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

10) chain B
residue 252
type
sequence Q
description BINDING SITE FOR RESIDUE CHO B 301
source : AC3

11) chain B
residue 18
type
sequence G
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

12) chain B
residue 21
type
sequence A
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

13) chain B
residue 22
type
sequence G
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

14) chain B
residue 23
type
sequence I
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

15) chain B
residue 42
type
sequence D
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

16) chain B
residue 43
type
sequence I
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

17) chain B
residue 67
type
sequence C
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

18) chain B
residue 68
type
sequence D
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

19) chain B
residue 69
type
sequence I
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

20) chain B
residue 95
type
sequence N
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

21) chain B
residue 97
type
sequence G
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

22) chain B
residue 144
type
sequence I
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

23) chain B
residue 145
type
sequence T
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

24) chain B
residue 159
type
sequence Y
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

25) chain B
residue 163
type
sequence K
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

26) chain B
residue 189
type
sequence P
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

27) chain B
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

28) chain B
residue 192
type
sequence I
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

29) chain B
residue 194
type
sequence T
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

30) chain B
residue 196
type
sequence A
description BINDING SITE FOR RESIDUE NAI B 302
source : AC4

31) chain B
residue 159
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 159
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI2

33) chain B
residue 23
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI2

34) chain B
residue 99
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI2

35) chain B
residue 146
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI2

36) chain B
residue 151
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI2

37) chain B
residue 192
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI3

38) chain B
residue 42
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI3

39) chain B
residue 68
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI3

40) chain B
residue 95
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI3

41) chain B
residue 163
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC
source Swiss-Prot : SWS_FT_FI3

42) chain B
residue 146
type SITE
sequence S
description Transition state stabilizer => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677
source Swiss-Prot : SWS_FT_FI4

43) chain B
residue 163
type SITE
sequence K
description Lowers pKa of active site Tyr => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677
source Swiss-Prot : SWS_FT_FI5


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