eF-site ID 1fm9-ABDE PDB Code 1fm9 Chain A, B, D, E click to enlarge Title THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES. Classification TRANSCRIPTION Compound RETINOIC ACID RECEPTOR RXR-ALPHA Source Homo sapiens (Human) (O43793) Sequence A:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP B:  HKILHRLLQE D:  PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKS PFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGC QFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEI IYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFME PKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI VTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY E:  ERHKILHRLLQEGSPS Description Functional site 1) chain D residue 280 type sequence R description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 2) chain D residue 282 type sequence F description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 3) chain D residue 284 type sequence G description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 4) chain D residue 285 type sequence C description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 5) chain D residue 286 type sequence Q description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 6) chain D residue 289 type sequence S description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 7) chain D residue 323 type sequence H description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 8) chain D residue 327 type sequence Y description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 9) chain D residue 330 type sequence L description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 10) chain D residue 341 type sequence I description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 11) chain D residue 348 type sequence M description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 12) chain D residue 360 type sequence F description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 13) chain D residue 364 type sequence M description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 14) chain D residue 449 type sequence H description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 15) chain D residue 465 type sequence L description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 16) chain D residue 469 type sequence L description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 17) chain D residue 473 type sequence Y description BINDING SITE FOR RESIDUE 570 D 200 source : AC1 18) chain A residue 271 type sequence A description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 19) chain A residue 275 type sequence Q description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 20) chain A residue 305 type sequence W description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 21) chain A residue 313 type sequence F description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 22) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 23) chain A residue 326 type sequence L description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 24) chain A residue 327 type sequence A description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 25) chain A residue 432 type sequence C description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 26) chain A residue 435 type sequence H description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 27) chain A residue 436 type sequence L description BINDING SITE FOR RESIDUE 9CR A 201 source : AC2 28) chain A residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3 29) chain E residue 699 type MOD_RES sequence P description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 449 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 473 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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