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eF-site ID
|
1fkp-B |
|
PDB Code
|
1fkp |
|
Chain
|
B |
|
click to enlarge
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Title
|
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
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Classification
|
TRANSFERASE |
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Compound
|
HIV-1 RT, A-CHAIN |
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Source
|
null (POL_HV1H2) |
|
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Sequence
|
B: |
IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKE
GKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRT
QDFPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFT
IPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF
RKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLR
WGELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQI
YPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREIL
KEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFK
LPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLE
KEPIVGAE
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Description
|
(1) |
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
402 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
2)
|
chain |
B |
| residue |
415 |
| type |
SITE |
| sequence |
E
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
B |
| residue |
111 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
187 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|