eF-site ID 1fkp-A PDB Code 1fkp Chain A click to enlarge Title CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE Classification TRANSFERASE Compound HIV-1 RT, A-CHAIN Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLX KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF YVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQ IIEQLIKKEKVYLAWVPAHKGI Description (1)  CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 3) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 4) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 5) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 6) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 7) chain A residue 189 type sequence V description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 8) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 9) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 10) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 11) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC1 12) chain A residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 13) chain A residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 14) chain A residue 499 type SITE sequence S description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 1 type SITE sequence P description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 441 type SITE sequence Y description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI6

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