eF-site ID 1fk9-A PDB Code 1fk9 Chain A click to enlarge Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) Classification TRANSFERASE Compound HIV-1 RT, A-CHAIN Source null (POL_HV1H2) Sequence A:  PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK EGKISKIGPENPYNTPVFAITKWRKLVDFRELNKRTQDFW EVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYT AFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL EPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQH LLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPE KDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKA LTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAE IQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQL TEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQA TWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDAGYVT NRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDS QYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAH Description (1)  HIV-1 REVERSE TRANSCRIPTASE (E.C.2.7.7.49) :DMP-266(EFAVIRENZ) COMPLEX Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 3) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 4) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 5) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 6) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 7) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 8) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 9) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 10) chain A residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 12) chain A residue 441 type SITE sequence Y description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 13) chain A residue 499 type SITE sequence S description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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