eF-site ID 1fdh-AB PDB Code 1fdh Chain A, B click to enlarge Title STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN Classification OXYGEN TRANSPORT Compound HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) Source Homo sapiens (Human) (HBG1_HUMAN) Sequence A:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR B:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR Description Functional site 1) chain A residue 42 type sequence Y description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 2) chain A residue 43 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 3) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 4) chain A residue 46 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 5) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 6) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 7) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 8) chain A residue 86 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 9) chain A residue 87 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 10) chain A residue 91 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 11) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 12) chain A residue 97 type sequence N description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 13) chain A residue 98 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 14) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 15) chain A residue 136 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 16) chain B residue 42 type sequence Y description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 17) chain B residue 43 type sequence F description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 18) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 19) chain B residue 46 type sequence F description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 20) chain B residue 58 type sequence H description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 21) chain B residue 61 type sequence K description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 22) chain B residue 83 type sequence L description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 23) chain B residue 86 type sequence L description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 24) chain B residue 87 type sequence H description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 25) chain B residue 91 type sequence L description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 26) chain B residue 93 type sequence V description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 27) chain B residue 97 type sequence N description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 28) chain B residue 98 type sequence F description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 29) chain B residue 101 type sequence L description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 30) chain B residue 136 type sequence L description BINDING SITE FOR RESIDUE HEM B 142 source : AC3 31) chain B residue 72 type sequence H description BINDING SITE FOR RESIDUE HEM H 147 source : AC4 32) chain A residue 103 type MOD_RES sequence H description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 33) chain A residue 125 type MOD_RES sequence L description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 34) chain A residue 132 type MOD_RES sequence V description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 35) chain A residue 139 type MOD_RES sequence K description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 36) chain B residue 103 type MOD_RES sequence H description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 37) chain B residue 125 type MOD_RES sequence L description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 38) chain B residue 132 type MOD_RES sequence V description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 39) chain B residue 139 type MOD_RES sequence K description Phosphoserine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI10 40) chain A residue 109 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 41) chain A residue 135 type MOD_RES sequence V description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 42) chain A residue 138 type MOD_RES sequence S description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 43) chain B residue 109 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 44) chain B residue 135 type MOD_RES sequence V description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 45) chain B residue 138 type MOD_RES sequence S description Phosphothreonine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI11 46) chain A residue 92 type MOD_RES sequence R description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 47) chain A residue 107 type MOD_RES sequence V description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 48) chain A residue 109 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 49) chain A residue 122 type MOD_RES sequence H description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 50) chain A residue 134 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 51) chain B residue 9 type MOD_RES sequence N description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 52) chain B residue 14 type MOD_RES sequence W description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 53) chain B residue 25 type MOD_RES sequence G description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 54) chain B residue 30 type MOD_RES sequence E description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 46 type MOD_RES sequence F description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 56) chain B residue 48 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 57) chain B residue 53 type MOD_RES sequence A description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 58) chain B residue 56 type MOD_RES sequence K description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 60 type MOD_RES sequence K description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 60) chain B residue 92 type MOD_RES sequence R description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 61) chain B residue 107 type MOD_RES sequence V description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 62) chain B residue 109 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 63) chain B residue 122 type MOD_RES sequence H description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 64) chain B residue 134 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 46 type MOD_RES sequence F description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 66) chain A residue 48 type MOD_RES sequence L description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 53 type MOD_RES sequence A description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 68) chain A residue 56 type MOD_RES sequence K description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 69) chain A residue 60 type MOD_RES sequence K description Phosphothreonine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 17 type MOD_RES sequence V description S-nitrosocysteine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI6 71) chain B residue 41 type MOD_RES sequence T description S-nitrosocysteine => ECO:0000250|UniProtKB:P68871 source Swiss-Prot : SWS_FT_FI6 72) chain A residue 8 type CARBOHYD sequence T description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 73) chain A residue 17 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 74) chain A residue 41 type CARBOHYD sequence T description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 75) chain B residue 8 type CARBOHYD sequence T description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 76) chain B residue 17 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 77) chain B residue 41 type CARBOHYD sequence T description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 78) chain A residue 62 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 79) chain B residue 62 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 80) chain A residue 25 type MOD_RES sequence G description Phosphotyrosine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI9 81) chain B residue 25 type MOD_RES sequence G description Phosphotyrosine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI9

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