eF-site ID 1fcm-B PDB Code 1fcm Chain B click to enlarge Title CRYSTAL STRUCTURE OF THE E.COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, CLOXACILLIN Classification hydrolase/antibiotic Compound BETA-LACTAMASE Source null (AMPC_ECOLI) Sequence B:  APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTW GYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEI KLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLLVPD EVKSSSDLLRFYQNWQPAWAPGTQRLEANSSIGLFGALAV KPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGY REGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDI NEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSI INGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFG SYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ Description Functional site 1) chain B residue 1 type sequence A description BINDING SITE FOR RESIDUE CXU A 961 source : AC1 2) chain B residue 61 type sequence S description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 3) chain B residue 117 type sequence L description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 4) chain B residue 147 type sequence E description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 5) chain B residue 149 type sequence N description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 6) chain B residue 218 type sequence Y description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 7) chain B residue 286 type sequence N description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 8) chain B residue 312 type sequence K description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 9) chain B residue 313 type sequence T description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 10) chain B residue 314 type sequence G description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 11) chain B residue 315 type sequence A description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 12) chain B residue 316 type sequence T description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 13) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 14) chain B residue 343 type sequence N description BINDING SITE FOR RESIDUE CXU B 961 source : AC2 15) chain B residue 61 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10102, ECO:0000269|PubMed:6795623 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 147 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 17) chain B residue 312 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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