eF-site ID 1fa0-AB PDB Code 1fa0 Chain A, B click to enlarge Title STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP Classification TRANSFERASE Compound POLY(A)-POLYMERASE Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PAP_YEAST) Sequence A:  SQKVFGITGPVSTVGATAAENKLNDSLIQELKKEGSFETE QETANRVQVLKILQELAQRFVYEVSKKKNMSDGMARDAGG KIFTYGSYRLGVHGPGSDIDTLVVVPKHVTREDFFTVFDS LLRERKELDEIAPVPDAFVPIIKIKFSGISIDLICARLDQ PQVPLSLTLSDKNLLRNLDEKDLRALNGTRVTDEILELVP KPNVFRIALRAIKLWAQRRAVYANIFGFPGGVAWAMLVAR ICQLYPNACSAVILNRFFIILSEWNWPQPVILKPIEDGPL QVRVWNPKIYAQDRSHRMPVITPAYPSMCATHNITESTKK VILQEFVRGVQITNDIFSNKKSWANLFEKNDFFFRYKFYL EITAYTRGSDEQHLKWSGLVESKVRLLVMKLEVLAGIKIA HPFTKPFESSYCCPTEDDYEMIQDKLKLVTDENKEEESIK DAPKAYLSTMYIGLDFNIENKKEKVDIHIPCTEFVNLCRS FNEDYGDHKVFNLALRFVKGYDLPDEVFD B:  SSQKVFGITGPVSTVGATAAENKLNDSLIQELKKEGSFET EQETANRVQVLKILQELAQRFVYEVSKKKNMSDGMARDAG GKIFTYGSYRLGVHGPGSDIDTLVVVPKHVTREDFFTVFD SLLRERKELDEIAPVPDAFVPIIKIKFSGISIDLICARLD QPQVPLSLTLSDKNLLRNLDEKDLRALNGTRVTDEILELV PKPNVFRIALRAIKLWAQRRAVYANIFGFPGGVAWAMLVA RICQLYPNACSAVILNRFFIILSEWNWPQPVILKPIEDGP LQVRVWNPKIYAQDRSHRMPVITPAYPSMCATHNITESTK KVILQEFVRGVQITNDIFSNKKSWANLFEKNDFFFRYKFY LEITAYTRGSDEQHLKWSGLVESKVRLLVMKLEVLAGIKI AHPFTKPFESSYCCPTEDDYEMIQDKYGSHKTETALNALK LVTPKAYLSTMYIGLDFNIVDIHIPCTEFVNLCRSFNEDY GDHKVFNLALRFVKGYDLPDEVFDENEKRPS Description Functional site 1) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE MN A 600 source : AC1 2) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE MN A 600 source : AC1 3) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE MN A 601 source : AC2 4) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE MN A 601 source : AC2 5) chain A residue 154 type sequence D description BINDING SITE FOR RESIDUE MN A 601 source : AC2 6) chain B residue 89 type sequence S description BINDING SITE FOR RESIDUE MN B 602 source : AC3 7) chain B residue 100 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC3 8) chain B residue 102 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC3 9) chain B residue 100 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC4 10) chain B residue 102 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC4 11) chain B residue 154 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC4 12) chain A residue 87 type sequence Y description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 13) chain A residue 88 type sequence G description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 14) chain A residue 89 type sequence S description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 15) chain A residue 99 type sequence S description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 16) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 17) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE 3AT A 604 source : AC5 18) chain B residue 89 type sequence S description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 19) chain B residue 99 type sequence S description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 20) chain B residue 100 type sequence D description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 21) chain B residue 102 type sequence D description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 22) chain B residue 140 type sequence F description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 23) chain B residue 215 type sequence K description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 24) chain B residue 234 type sequence V description BINDING SITE FOR RESIDUE 3AT B 605 source : AC6 25) chain A residue 87 type sequence Y description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 26) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 27) chain A residue 141 type sequence V description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 28) chain A residue 154 type sequence D description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 29) chain A residue 156 type sequence I description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 30) chain A residue 186 type sequence R description BINDING SITE FOR RESIDUE 3AD A 606 source : AC7 31) chain B residue 87 type sequence Y description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 32) chain B residue 102 type sequence D description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 33) chain B residue 140 type sequence F description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 34) chain B residue 141 type sequence V description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 35) chain B residue 154 type sequence D description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 36) chain B residue 186 type sequence R description BINDING SITE FOR RESIDUE 3AD B 607 source : AC8 37) chain A residue 88 type sequence G description BINDING SITE FOR RESIDUE POP A 817 source : AC9 38) chain A residue 89 type sequence S description BINDING SITE FOR RESIDUE POP A 817 source : AC9 39) chain A residue 92 type sequence L description BINDING SITE FOR RESIDUE POP A 817 source : AC9 40) chain A residue 94 type sequence V description BINDING SITE FOR RESIDUE POP A 817 source : AC9 41) chain A residue 194 type sequence T description BINDING SITE FOR RESIDUE POP A 817 source : AC9 42) chain A residue 211 type sequence L description BINDING SITE FOR RESIDUE POP A 817 source : AC9 43) chain A residue 215 type sequence K description BINDING SITE FOR RESIDUE POP A 817 source : AC9 44) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE POP A 817 source : AC9 45) chain A residue 233 type sequence G description BINDING SITE FOR RESIDUE POP A 817 source : AC9 46) chain A residue 234 type sequence V description BINDING SITE FOR RESIDUE POP A 817 source : AC9 47) chain A residue 89 type catalytic sequence S description 796 source MCSA : MCSA1 48) chain A residue 100 type catalytic sequence D description 796 source MCSA : MCSA1 49) chain A residue 102 type catalytic sequence D description 796 source MCSA : MCSA1 50) chain A residue 154 type catalytic sequence D description 796 source MCSA : MCSA1 51) chain A residue 215 type catalytic sequence K description 796 source MCSA : MCSA1 52) chain A residue 224 type catalytic sequence Y description 796 source MCSA : MCSA1 53) chain B residue 89 type catalytic sequence S description 796 source MCSA : MCSA2 54) chain B residue 100 type catalytic sequence D description 796 source MCSA : MCSA2 55) chain B residue 102 type catalytic sequence D description 796 source MCSA : MCSA2 56) chain B residue 154 type catalytic sequence D description 796 source MCSA : MCSA2 57) chain B residue 215 type catalytic sequence K description 796 source MCSA : MCSA2 58) chain B residue 224 type catalytic sequence Y description 796 source MCSA : MCSA2 59) chain A residue 87 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 60) chain B residue 233 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 99 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 215 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 224 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 233 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 87 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 99 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 215 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 224 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17850751 source Swiss-Prot : SWS_FT_FI1 69) chain A residue 100 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 70) chain A residue 102 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 71) chain A residue 154 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 72) chain B residue 100 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 73) chain B residue 102 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 74) chain B residue 154 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 75) chain A residue 140 type SITE sequence F description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 76) chain B residue 145 type SITE sequence K description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 77) chain B residue 294 type SITE sequence Q description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 78) chain B residue 314 type SITE sequence H description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 79) chain B residue 315 type SITE sequence N description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 80) chain B residue 387 type SITE sequence R description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 81) chain B residue 392 type SITE sequence K description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 82) chain B residue 487 type SITE sequence E description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 83) chain A residue 145 type SITE sequence K description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 84) chain A residue 294 type SITE sequence Q description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 85) chain A residue 314 type SITE sequence H description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 86) chain A residue 315 type SITE sequence N description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 87) chain A residue 387 type SITE sequence R description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 88) chain A residue 392 type SITE sequence K description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 89) chain A residue 487 type SITE sequence E description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 90) chain B residue 140 type SITE sequence F description Interaction with RNA source Swiss-Prot : SWS_FT_FI3 91) chain A residue 452 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI4

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