eF-site ID 1f73-D PDB Code 1f73 Chain D click to enlarge Title CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL Classification LYASE Compound N-ACETYL NEURAMINATE LYASE Source null (NANA_HAEIN) Sequence D:  MRDLKGIFSALLVSFNEDGTINEKGLRQIIRHNIDKMKVD GLYVGGSTGENFMLSTEEKKEIFRIAKDEAKDQIALIAQV GSVNLKEAVELGKYATELGYDCLSAVTPFYYKFSFPEIKH YYDTIIAETGSNMIVYSIPNMGIEQFGELYKNPKVLGVKF TAGDFYLLERLKKAYPNHLIWAGFDEMMLPAASLGVDGAI GSTFNVNGVRARQIFELTKAGKLKEALEIQHVTNDLIEGI LANGLYLTIKELLKLEGVDAGYCREPMTSKATAEQVAKAK DLKAKFLS Description Functional site 1) chain D residue 10 type sequence A description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 2) chain D residue 43 type sequence Y description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 3) chain D residue 46 type sequence G description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 4) chain D residue 47 type sequence S description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 5) chain D residue 48 type sequence T description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 6) chain D residue 164 type sequence K description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 7) chain D residue 188 type sequence G description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 8) chain D residue 189 type sequence F description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 9) chain D residue 190 type sequence D description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 10) chain D residue 191 type sequence E description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 11) chain D residue 206 type sequence G description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 12) chain D residue 207 type sequence S description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 13) chain D residue 250 type sequence L description BINDING SITE FOR RESIDUE HMN D 703 source : AC4 14) chain D residue 47 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 15) chain D residue 48 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 16) chain D residue 166 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 17) chain D residue 188 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 18) chain D residue 190 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 19) chain D residue 191 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 20) chain D residue 207 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 21) chain D residue 136 type ACT_SITE sequence Y description Proton donor => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 164 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 source Swiss-Prot : SWS_FT_FI2

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