eF-site ID 1f73-A PDB Code 1f73 Chain A click to enlarge Title CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL Classification LYASE Compound N-ACETYL NEURAMINATE LYASE Source null (NANA_HAEIN) Sequence A:  MRDLKGIFSALLVSFNEDGTINEKGLRQIIRHNIDKMKVD GLYVGGSTGENFMLSTEEKKEIFRIAKDEAKDQIALIAQV GSVNLKEAVELGKYATELGYDCLSAVTPFYYKFSFPEIKH YYDTIIAETGSNMIVYSIPNMGIEQFGELYKNPKVLGVKF TAGDFYLLERLKKAYPNHLIWAGFDEMMLPAASLGVDGAI GSTFNVNGVRARQIFELTKAGKLKEALEIQHVTNDLIEGI LANGLYLTIKELLKLEGVDAGYCREPMTSKATAEQVAKAK DLKAKFLS Description Functional site 1) chain A residue 10 type sequence A description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 2) chain A residue 43 type sequence Y description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 3) chain A residue 46 type sequence G description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 4) chain A residue 47 type sequence S description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 5) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 6) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 7) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 8) chain A residue 190 type sequence D description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 9) chain A residue 191 type sequence E description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 10) chain A residue 206 type sequence G description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 11) chain A residue 207 type sequence S description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 12) chain A residue 250 type sequence L description BINDING SITE FOR RESIDUE HMN A 700 source : AC1 13) chain A residue 39-64 type prosite sequence VDGLYVGGSTGENFMLSTEEKKEIFR description SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. VdGLYvGGstgenfmLstEekkeifR source prosite : PS00217 14) chain A residue 1-4 type prosite sequence MRDL description TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MRDL source prosite : PS00228 15) chain A residue 41-58 type prosite sequence GLYVGGSTGENFMLSTEE description DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGENfmlsteE source prosite : PS00665 16) chain A residue 136-166 type prosite sequence YSIPNMGIEQFGELYKNPKVLGVKFT description DHDPS_2 Dihydrodipicolinate synthase signature 2. YSIPflTgvnMgieqfgelyknpk.VlGVKFT source prosite : PS00666 17) chain A residue 190 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 191 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 207 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 188 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 47 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 48 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 166 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01237 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 136 type ACT_SITE sequence Y description Proton donor => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 164 type ACT_SITE sequence K description Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:11031117 source Swiss-Prot : SWS_FT_FI2

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