eF-site ID 1f3m-D PDB Code 1f3m Chain D click to enlarge Title CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 Classification TRANSFERASE Compound SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA Source Homo sapiens (Human) (PAK1_HUMAN) Sequence D:  SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAM DVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF GFCAQITPGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDF LNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAA KEATK Description Functional site 1) chain D residue 325 type sequence P description BINDING SITE FOR RESIDUE IOD D 604 source : AC4 2) chain D residue 268 type sequence K description BINDING SITE FOR RESIDUE IOD C 610 source : AC9 3) chain D residue 399 type sequence M description BINDING SITE FOR RESIDUE IOD D 619 source : BC7 4) chain D residue 364 type sequence G description BINDING SITE FOR RESIDUE IOD D 621 source : BC9 5) chain D residue 265 type sequence D description BINDING SITE FOR RESIDUE IOD D 622 source : CC1 6) chain D residue 400 type sequence D description BINDING SITE FOR RESIDUE IOD D 625 source : CC4 7) chain D residue 323 type sequence K description BINDING SITE FOR RESIDUE IOD D 628 source : CC6 8) chain D residue 324 type sequence N description BINDING SITE FOR RESIDUE IOD D 628 source : CC6 9) chain D residue 389 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI1 10) chain D residue 276 type BINDING sequence I description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 299 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 345 type BINDING sequence E description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 13) chain D residue 285 type MOD_RES sequence Y description Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089 source Swiss-Prot : SWS_FT_FI3

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