eF-site ID 1f3m-C PDB Code 1f3m Chain C click to enlarge Title CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 Classification TRANSFERASE Compound SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA Source Homo sapiens (Human) (PAK1_HUMAN) Sequence C:  SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAM DVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF GFCAQITTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAI EMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFR DFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIA AAKEATK Description Functional site 1) chain C residue 468 type sequence N description BINDING SITE FOR RESIDUE IOD C 602 source : AC2 2) chain C residue 470 type sequence L description BINDING SITE FOR RESIDUE IOD C 602 source : AC2 3) chain C residue 466 type sequence N description BINDING SITE FOR RESIDUE IOD C 610 source : AC9 4) chain C residue 364 type sequence G description BINDING SITE FOR RESIDUE IOD C 611 source : BC1 5) chain C residue 325 type sequence P description BINDING SITE FOR RESIDUE IOD C 613 source : BC2 6) chain C residue 444 type sequence K description BINDING SITE FOR RESIDUE IOD C 623 source : CC2 7) chain C residue 347 type sequence L description BINDING SITE FOR RESIDUE IOD D 625 source : CC4 8) chain C residue 514 type sequence E description BINDING SITE FOR RESIDUE IOD C 627 source : CC5 9) chain C residue 385-397 type prosite sequence VIHRDIKSDNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL source prosite : PS00108 10) chain C residue 389 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI1 11) chain C residue 276 type BINDING sequence I description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 12) chain C residue 299 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 13) chain C residue 345 type BINDING sequence E description BINDING => ECO:0000269|PubMed:22153498 source Swiss-Prot : SWS_FT_FI2 14) chain C residue 285 type MOD_RES sequence Y description Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 423 type MOD_RES sequence T description Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945 source Swiss-Prot : SWS_FT_FI4

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